Metastable peak shapes induced by internal energy release in electrostatic mirror time-of-flight mass spectrometers

Ioanoviciu, D.; Yefchak, George E.; Enke, Christie G.

doi:10.1016/0168-1176(91)80001-4

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…Here, secondary laser excitation allows mass‐selective fragmentation 34, 48. In addition, laser excitation may induce metastable decay of molecular ions; in this case, the special features of reflectron time‐of‐flight mass analyzers with respect to metastable decay in the field‐free region39, 49, 50 (sometimes called post‐source decay) allow tandem mass spectrometry with low additional effort, again. Whichever method is used, if isobaric molecular species have different secondary mass spectra, then this is another method of selective laser‐induced mass spectrometry, which may compensate for reduced selectivity of the ionization step (e.g.…”

Section: Drawbacks Of Resonant Laser Mass Spectrometry and Approachesmentioning

confidence: 99%

Laser mass spectrometry for environmental and industrial chemical trace analysis

Boesl

2000

J. Mass Spectrom.

105

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Resonant laser mass spectrometry is a promising method for chemical trace analysis since it combines selectivity, sensitivity and rapidity of measurement. It is a two‐dimensional technique incorporating medium‐ or high‐resolution UV spectroscopy and time‐of‐flight mass spectrometry. No sample preparation and chemical clean‐up is necessary to reach detection limits in the sub‐ppb range even when highly complicated mixtures of chemical species are analyzed. After an introduction to the principles of resonant laser mass spectrometry, illustrative examples of applications are presented. Drawbacks, possibilities of overcoming them, some interesting features and future developments of resonant laser mass spectrometry are discussed. Copyright © 2000 John Wiley & Sons, Ltd.

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Section: Drawbacks Of Resonant Laser Mass Spectrometry and Approachesmentioning

confidence: 99%

Laser mass spectrometry for environmental and industrial chemical trace analysis

Boesl

2000

J. Mass Spectrom.

105

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“…It is worth noting that in the DE mode the peaks of PSD fragment ions tend to adopt a shape which can be predicted if the effect of kinetic energy release on the spread of ion amval times is taken into account. 25 In contrast to the quasiLorentzian profile of the precursor ion signal, PSD signals under DE look in fact more like the 'Eiffel tower', i.e. out of a rather wide base they form needle-like tops with symmetrical flanks of steadily increasing slope.…”

Section: General Aspects Of Psd Fragment Ion Formation and Analysis Amentioning

confidence: 96%

Post-source Decay and Delayed Extraction in Matrix-assisted Laser Desorption/Ionization-Reflectron Time-of-Flight Mass Spectrometry. Are There Trade-offs?

Kaufmann

Chaurand

Kirsch

et al. 1996

Rapid Commun. Mass Spectrom.

135

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By the incorporation of delayed extraction (DE) into matrix-assisted laser desorption/ionization time-of-flight mass spectrometry a dramatic improvement of performance with respect to sensitivity, mass resolution and mass accuracy of precursor ions up to approximately 10 kDa has been achieved. Since DE reduces collisional in-source activation to a large extent, the rate of subsequent metastable decay is considerably reduced. Results are presented which demonstrate that under DE the loss of total post-source decay (PSD) fragment ion yield can be as large as one order of magnitude but that, in terms of sensitivity, part of this loss is balanced by a better S/N ratio which results from a significantly improved mass resolution of the PSD fragment ions (M/delta M up to 1800 compared with M/delta M = 200-500 under prompt extraction). While this compensatory effect is true for the middle to high mass range of PSD fragment ions, it gradually vanishes towards the low mass end of the PSD mass scale where, in the case of linear peptides some important information (immonium ions) is lost. It appears, however, that in the majority of practical PSD work, DE improves the qualty of the PSD spectra and that high energy collisional post-source activation can compensate for the occasional loss of analytical information.

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“…Here, secondary laser excitation allows mass-selective fragmentation. 34,48 In addition, laser excitation may induce metastable decay of molecular ions; in this case, the special features of reflectron time-offlight mass analyzers with respect to metastable decay in the field-free region 39,49,50 (sometimes called post-source decay) allow tandem mass spectrometry with low additional effort, again. Whichever method is used, if isobaric molecular species have different secondary mass spectra, then this is another method of selective laser-induced mass spectrometry, which may compensate for reduced selectivity of the ionization step (e.g.…”

Section: Drawbacks Of Resonant Laser Mass Spectrometry and Approachesmentioning

confidence: 99%

Resonant laser mass spectrometry for environmental and industrial chemical trace analysis

Boesl¹,

Rink²,

Distelrath

et al. 2001

AIP Conference Proceedings

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Resonant laser mass spectrometry is a promising method for chemical trace analysis since it combines selectivity, sensitivity and rapidity of measurement. It is a two-dimensional technique incorporating medium-or highresolution UV spectroscopy and time-of-flight mass spectrometry. No sample preparation and chemical clean-up is necessary to reach detection limits in the sub-ppb range even when highly complicated mixtures of chemical species are analyzed. After an introduction to the principles of resonant laser mass spectrometry, illustrative examples of applications are presented. Drawbacks, possibilities of overcoming them, some interesting features and future developments of resonant laser mass spectrometry are discussed.

show abstract

Metastable peak shapes induced by internal energy release in electrostatic mirror time-of-flight mass spectrometers

Cited by 8 publications

References 8 publications

Laser mass spectrometry for environmental and industrial chemical trace analysis

Laser mass spectrometry for environmental and industrial chemical trace analysis

Post-source Decay and Delayed Extraction in Matrix-assisted Laser Desorption/Ionization-Reflectron Time-of-Flight Mass Spectrometry. Are There Trade-offs?

Resonant laser mass spectrometry for environmental and industrial chemical trace analysis

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