Metastable zone width, crystal nucleation and growth kinetics measurement in anti-solvent crystallization of β-artemether in the mixture of ethanol and water

Abstract

Please cite this article in press as: Zhang, Y., et al., Metastable zone width, crystal nucleation and growth kinetics measurement in anti-solvent crystallization of ␤-artemether in the mixture of ethanol and water. Chem. Eng. Res. Des. (2014), http://dx.

Influence of solution chemistry on the solubility, crystallisability and nucleation behaviour of eicosane in toluene : acetone mixed-solvents

“…Such a structure could disrupt the diffusive transport of eicosane molecules into the prenucleation clusters, seen when toluene is in excess, given acetone's limited intermolecular interactions with eicosane. This would have the effect of lowering the attachment frequency of eicosane to a growing cluster, hence reducing the nucleation rate constant, K J , and, as such, the rate of nucleation (eqn (12)). Thus, only some of the eicosane clusters might reach a critical cluster size and be able to nucleate, before a stable equilibrium in solution was reached.…”

Time-Resolved X-ray Phase-Contrast Imaging (XPCI) of Nucleation and Crystal Growth in the Anti-Solvent Crystallization of Lovastatin

“…Lovastatin is widely known to exhibit a needle-like habit 49 that causes problems with processing and manufacturing of API [49][50][51][52][53][54][55][56][57][58] during filtering 58 and due to poor flow properties. 59 This morphology is known to arise from solvent interactions leading to slow growth of various facets.…”

On-line observation of the crystal growth in the case of the non-typical spherical crystallization methods of ambroxol hydrochloride

“…If we possess facilities for the use of on-line or in-line imaging or particle size observation methods, a real-time observation of nucleation and crystal growth can be achieved. The focused beam reflectance measuring method (FBRM) is a modern and accurate method for in-line or even on-line measurements [17]. [18].…”