Metastasis of primary melanoma to two separate lymph node basins: Prognostic significance

Dale, Paul S.; Foshag, Leland J.; Wanek, Leslie A.; Morton, Donald L.

doi:10.1007/bf02316805

Cited by 27 publications

(17 citation statements)

References 6 publications

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“…Dale et al 26 found that 5-year survival in patients with dual-basin involvement was lower than that of patients with single-basin involvement (33% vs. 48%; P ϭ .001) in a study of 406 patients undergoing regional lymphadenectomy of two separate lymph node basins. Moreover, by multivariate analysis, the number of basins involved, as well as number of nodes involved, were significant independent prognostic factors for survival.…”

Section: Discussionmentioning

confidence: 95%

Significance of Multiple Nodal Basin Drainage in Truncal Melanoma Patients Undergoing Sentinel Lymph Node Biopsy

et al. 2000

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Section: Discussionmentioning

confidence: 95%

Significance of Multiple Nodal Basin Drainage in Truncal Melanoma Patients Undergoing Sentinel Lymph Node Biopsy

et al. 2000

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“…In contrast, Jiminez et al [ 8 ] found that patients with MLBD had a worse prognosis, independent of SLN status. Dale et al [ 14 ] also showed that overall survival was reduced in patients with dual basin involvement versus single basin involvement (median overall survival of 33 vs 56 months). A further interesting study by Wall et al [ 15 ] found that multiple lymphatic channels to a single basin were an independent risk factor for locoregional recurrence as well as increased mortality.…”

Section: Discussionmentioning

confidence: 99%

Sentinel node studies in truncal melanoma: does an increased number of draining basins correlate with an increased risk of lymph metastasis?

Bailey¹,

Quigley²,

Hall³

et al. 2012

Cancer Imaging

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Objectives: To assess whether an association exists between drainage to multiple basins and lymphatic metastasis in patients with truncal melanoma. Methods: We retrospectively reviewed 227 patients with primary malignant melanoma between January 2006 and December 2009. All patients received an intradermal injection of 99mTc-nanocolloid and lymphoscintigraphy followed by sentinel node biopsy. Pre-staging histology with Breslow thickness from excision biopsy was also obtained. Results: 82/227 (36%) patients with primary truncal melanoma were identified. Nodal histology was positive for metastatic disease in 27/82 (32.9%) patients. Of these 27, 15 had 1 basin of drainage, 7 had 2 basins of drainage and 5 had 3 basins of drainage. Of the 55 node-negative patients, 35 had 1 basin, 18 had 2 basins and 2 had 3 basins of drainage. We found no significant correlation with sentinel node positivity and those that had ≥2 drainage basins. Breslow thickness was available in 65/82(79.2%) patients. Sentinel node biopsy was positive in 6/28 patients who had <1.5 mm thickness, 8/14 who had a 1.5–3.9 mm thickness and 9/23 who had ≥4 mm thickness. There was a significant correlation between Breslow thickness of ≥4 mm and nodal positivity (P = 0.03). Conclusion: This study demonstrates no association between multiple drainage basins and sentinel node histology. Sentinel lymph node status did correlate with Breslow thickness.

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“…Although spread of extremity lesions is often predictable, the use of sentinel lymph node mapping has shown that a high proportion of head, neck, and trunk melanomas drain to unexpected nodal basins or have drainage to two lymph node basins. In addition, patients with disease in two nodal groups have a worse prognosis than those with disease in one nodal group (140). Results of only a single study (141) have suggested that FDG PET has a sensitivity near that of sentinel lymph node mapping, although it has been shown to have a specificity as high as 97% (142,143).…”

Section: Melanomamentioning

confidence: 97%

Molecular Imaging Techniques in Body Imaging

et al. 2007

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Molecular imaging of the body involves new techniques to image cellular biochemical processes, which results in studies with high sensitivity, specificity, and signal-to-background. The most prevalently used molecular imaging technique in body imaging is currently fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET). FDG PET has become the method of choice for the staging and restaging of many of the most common cancers, including lymphoma, lung cancer, breast cancer, and colorectal cancer. FDG PET has also become extremely valuable in monitoring the response to therapeutic drugs in many cancers. New PET agents, such as fluorothymidine and acetate, have also shown promise in the evaluation of response to therapy and in the staging of prostate cancer. Magnetic resonance (MR) spectroscopy has shown promise in the evaluation of prostate cancer. Breast cancer evaluation benefits from advances in spectroscopic imaging and contrast-enhanced kinetic evaluation of vascular permeability, which is altered in neoplastic processes because of release of angiogenic factors. Superparamagnetic iron oxide (SPIO) particles represent the first of an expanding line of MR contrast agents that target specific cellular processes. SPIO particles have also been used in the evaluation of the cirrhotic liver and at MR lymphangiography.

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Metastasis of primary melanoma to two separate lymph node basins: Prognostic significance

Cited by 27 publications

References 6 publications

Significance of Multiple Nodal Basin Drainage in Truncal Melanoma Patients Undergoing Sentinel Lymph Node Biopsy

Significance of Multiple Nodal Basin Drainage in Truncal Melanoma Patients Undergoing Sentinel Lymph Node Biopsy

Sentinel node studies in truncal melanoma: does an increased number of draining basins correlate with an increased risk of lymph metastasis?

Molecular Imaging Techniques in Body Imaging

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