Metastasis of the liver with a granulosa cell tumor of the ovary: A case report

Abstract

The present study describes the case of a 62 year-old female patient with a metastatic tumor in the right hemi-liver of >25 cm in diameter, who presented to The Affiliated Hospital of Guilin Medical University (Guangxi, China) with acute abdominal pain and severe malnutrition. Radical surgery was performed to remove the tumor by open surgery. A biopsy was not performed prior to the surgery, so the tumor was diagnosed as end-stage primary liver cancer (PLC) based solely on the character and appearance of the tumor on computed tomography prior to surgery. However, subsequent to the surgery, upon analysis by the Department of Pathology, the mass was identified as an ovarian granulosa cell tumor (GCT). These tumors occur rarely, representing only 2–3% of all ovarian tumors, and are well known for late recurrences, with an incidence of 25–30%. As metastasis of the liver with GCT is extremely rare and the data available on the subject is limited by the small number of studies, and due to the absence of a biopsy report prior to surgery, the patient was initially misdiagnosed with PLC. However, despite this misdiagnosis, a good result was obtained, as the patient was later diagnosed with GCT following a detailed pathological examination and was treated with rational therapy. The performance status and quality of life were significantly improved, and the patient remains disease-free at one year post-surgery.

Recurrence in Granulosa Cell Tumour of the Ovary- A Retrospective Study

“…5 Hepatic metastases are rare with an incidence of 5-6% of all GCT recurrences. 6 We found higher rate of hepatic metastasis compared to literature.…”

Metástasis pulmonar de tumor de células de la granulosa como recurrencia del tumor primario después de diez años del tratamiento quirúrgico

“…Normalmente, el diagnóstico es en estadio I (85-90%) y presentan un crecimiento lento con una diseminación local y recurrencia tardía (10 a 50%) y pueden manifestarse incluso 20 a 30 años posteriores al diagnóstico inicial. Las metástasis son raras y pueden ocurrir muchos años después, como en este caso, y ocurren a pulmón, hígado (5-6% de todas las recurrencias) y hueso (1,2,4,5,6). El seguimiento con Ca-125 y alfa inhibina sérica permitirán la identificación precoz de las recidivas y la respuesta a terapia en un 100% pero no mejorarían la sobrevida (3,5).…”

“…En general, tienen un buen pronóstico que depende del estadio clínico al momento del diagnóstico. Las recurrencias y metástasis son raras y generalmente ocurren en la zona pélvica (3,5,6).…”

Gastric Metastasis of an Ovarian Granulosa Cell Tumor Diagnosed in a Patient with Worsening Reflux

“…GCT is a rare sex cord-stromal tumor associated with low malignant potential. 1 This tumor has a strong tendency for late recurrences, with an incidence of 25–30%, and is associated with a poor prognosis. 1 Once the tumor recurs, it is fatal in 80% of cases.…”

“… 1 This tumor has a strong tendency for late recurrences, with an incidence of 25–30%, and is associated with a poor prognosis. 1 Once the tumor recurs, it is fatal in 80% of cases. Most recurrences occur within 10 years after the initial diagnosis (median 4–5 years).…”