Metástasis testicular como primera manifestación clínica de melanoma maligno de origen desconocido

Ibáñez, J.A. Contreras; Cueto, P. Muriel; Perea, J.

doi:10.4321/s0004-06142009000300008

Cited by 2 publications

(1 citation statement)

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“…On the other hand, non-neoplastic melanoblasts resulting from the migration of melanin-producing cells from the neural crest to mesodermal derivatives during embryologic development can explain the presence of melanocytes in the testis and support the possibility of a primary melanoma developing at this rare site. We report this case to emphasize the need for awareness of the possibility of the testis being the primary site in a bird with melanoma and to underline the necessity of considering a metastatic melanoma from unknown primary sites ( Katiyar et al., 2007 ; Contreras et al., 2009 ; Aslam et al., 2010 ).…”

Section: Discussionmentioning

confidence: 95%

Rhabdoid melanoma in a harpy eagle (Harpia harpyja)

Pinzón-Osorio

Ávila-Coy

Gómez

et al. 2021

Veterinary and Animal Science

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A 28-year-old male harpy eagle ( Harpia harpyja ) with a history of anorexia, hyporexia, lethargy, and progressive weight loss was found dead and submitted for post-mortem examination. Gross findings include dark brown discolouration of testes and lungs; the testes were bilaterally enlarged, glistening brown-grey to blackish in appearance, firm, smooth, and multilobulated. The lungs contained a mass with similar features to the testicles, irregularly shaped with multiple nodules. Histology of testis showed round, polygonal and pleomorphic cells, containing melanin pigments and a typical eosinophilic vacuole in their cytoplasm and with severe pleomorphism. An immunohistochemistry panel with Melan-A, vimentin, CK AE1/AE/3, MUM-1 and CD-68 were performed, yielding a positive reaction for Melan-A and vimentin. The morphology of the tumour cells, the presence of melanin pigment and the immunoreactivity for Melan-A and vimentin by the cells led to a diagnosis of rhabdoid melanoma. This is the first case of this pathology in the testis with lung metastasis in a harpy eagle.

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Section: Discussionmentioning

confidence: 95%