As variações nas funções termodinâmicas energia de Gibbs, entalpia e entropia para os processos de solução de uma série de sulfonamidas em cicloexano foram determinadas nas temperaturas de 20,0 a 40,0 °C. A energia de Gibbs de excesso e os coeficientes de atividade destes solutos também foram calculados. Estes resultados são discutidos em termos de interações soluto-solvente nestes sistemas.The thermodynamic functions Gibbs energy, enthalpy and entropy of solution in cyclohexane, were evaluated from solubility data for a group of sulfonamides over the temperature range from 20.0 to 40.0 °C. The excess Gibbs energy and the activity coefficients of the solutes were also determined. The results are discussed in terms of solute-solvent interactions.

The thermodynamics of partitioning of some structurally related sulfonamides have been determined in 1‐octanol–aqueous buffer and liposome systems. The partition coefficients were approximately tenfold higher in liposomes compared with 1‐octanol. The enthalpies of transfer from aqueous media to organic systems were positive in liposomes but negative or positive in 1‐octanol, whereas the entropies of transfer were positive in almost all cases. Copyright © 2002 John Wiley & Sons, Ltd.

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