Metastasising clear cell odontogenic carcinoma: a case report and review of the literature

Calcifying Epithelial Odontogenic Tumour with Clear Langerhans Cells: A Novel Variant, Report of a Case and Review of the Literature

“…The most difficult differential diagnosis is CCEOT versus clear cell odontogenic carcinoma (CCOC)/(hyalinizing) clear cell carcinoma (CCC). The distinction from CCOC/CCC is of paramount importance, since CCOCs and CCCs can be clinically aggressive with loco-regional recurrences and metastases to regional lymph nodes and distant sites [22,23]. This is in contrast to CCEOTs which tend to have an excellent prognosis when adequately excised [7].…”

Malignant Odontogenic Tumors: An Update on Selected Tumors

“…Hansen originally described it in 1985 as a benign but aggressive lesion, centrally located in the jaws, under the guise of clear cell odontogenic tumor [20]. Subsequent case reports and small series included additional clinical follow-up that documented the capacity of this neoplasm for local destructive growth with invasion of medullary bone, nerves, lymphatics, as well as regional lymph node and distant metastases (pulmonary, bone) [21][22][23]. The World Health Organization reclassified the tumor in 2005 as an odontogenic carcinoma ( Table 1).…”

Clear Cell Odontogenic Carcinoma—A Rare Case Report

“…Published literature showed that the anterior portions of the jaws especially the mandible of females is most frequently affected [4,7]. This is contrast with the case being in the male patient and occurring in the posterior mandible.…”

“…Kumar et al [7] also documented a case which metastasized to the 5th lumber vertebra and hip 3 years after the initial diagnosis, thus emphasizing the need for long-term follow up. Local recurrence is a common finding and cytologic atypia appears to worsen with recurrent lesions.…”