Metastasizing dermal squamomelanocytic tumour

Abstract

References1 Pool SE, Manieei F, Clark WH Jr, Harrist TJ. Dermal squamomelanocytic tumor: a unique biphenotypic neoplasm of uncertain biological potential. Hum Pathol 1999; 30: 525-529. 2 Dorić M, Radović S, Kuskunović S et al. Dermal squamomelanocytic tumor: neoplasm of uncertain biological potential. Bosn J Basic Med Sci 2008; 8: 152-155. 3 Rongioletti F, Baldari M, Carli C, Fiocca R. Squamomelanocytic tumor: a new case of a unique biphenotypic neoplasm of uncertain biological potential. J Cutan Pathol 2009; 36: 477-481. 4 Miteva M, Herschthal D, Ricotti C et al. A rare case of a cutaneous squamomelanocytic tumor: revisiting the histogenesis of combined neoplasms. Am J Dermatopathol 2009; 31: 599-603. 5 Rosen L, Benson J, Williams W et al. A malignant neoplasm with features of both squamous carcinoma and malignant melanoma.

Squamomelanocytic Tumor of the Nail Unit Metastasizing to a Sentinel Lymph Node: A Dermoscopic and Histologic Investigation

“…Although metastasis has not been reported in most known cases of SMT, a sentinel node micrometastasis of a lesion with a Breslow thickness of 4.3 mm was described recently [2], and one of two sentinel nodes of our patient showed a subcapsular melanoma micrometastasis. Thus, although the excellent long-term prognosis of such small metastases of melanoma did not necessitate further therapeutic action in our case [15], lymph node metastasis of SMT is quite possible.…”

“…To our knowledge, among the 13 cases in the world literature [1,2,3,4,5,6,7,8,9], this is the first reported SMT involving the nail unit (table 1). …”

“…Since the publication of a first case series in 1999 [1] only 9 more cases have been reported in the world literature [2,3,4,5,6,7,8,9]. The large majority of earlier cases (11 out of 12) involved chronically sun-exposed skin of the face and scalp area.…”

Locally Invasive Dermal Squamomelanocytic Tumor With Matrical Differentiation

“…The malignant melanocytic component is the potentially more aggressive tumor, and clinicopathologic questions often arise as to whether additional factors, such as ulceration, regression, and tumor thickness, are of any relevance to prognosis. In fact, the malignant melanocytic component of dermal squamomelanocytic tumors has been associated with possible regional metastasis, 8,9,31 which indicates a greater neoplastic potential of this entity than initially thought.…”

“…Only 11 cases of dermal squamomelanocytic tumors have been documented in the English literature (Table 1). [2][3][4][5][6][7][8][9] Dermal squamomelanocytic tumors demonstrate 2 phenotypically distinct but intermingled populations of malignant keratinocytes and melanocytes. As a result of the rarity of these tumors, there is no consensus on their classification and biologic behavior.…”