Metastatic adenocarcinoma of the scalp mimicking a kerion

Faust, Holly B.; Treadwell, Patricia

doi:10.1016/s0190-9622(08)81878-6

Cited by 12 publications

(21 citation statements)

References 2 publications

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“…The scalp is known to be a favored location for distant metastasis, with approximately 5% of cases involving this site. 1,3,34 In this study, 7% of cases had scalp metastases. In addition, many cases showed distant metastasis to the face (12%), including squamous cell carcinoma of the lung to the nasal tip, renal cell carcinoma to the chin, renal cell carcinoma to the nasal ala, transitional cell carcinoma of the bladder to the pre-auricular area, adenocarcinoma of the esophagus to the nasolabial fold, colonic adenocarcinoma to the face, and adenocarcinoma of unknown primary to the forehead.…”

Section: Location Of Metastasesmentioning

confidence: 50%

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Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal

2004

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Excluding the potential for age and gender bias in this study conducted in a VA setting, cutaneous metastases represent an uncommon, deadly, and late-developing occurrence in many patients. Compared with previous studies, lung carcinoma remains the most common of the cutaneous metastases, with a relative rise in the incidence of metastatic melanoma. The immunohistochemical battery of CK-7, CK-20, and S-100 is a helpful adjunct in narrowing the differential diagnosis of the primary site of a large proportion of cutaneous metastases, particularly tumors with an epithelioid appearance such as carcinomas and melanomas.

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Section: Location Of Metastasesmentioning

confidence: 50%

“…Cutaneous lesions tend to occur in close proximity to the primary tumor, 3 although there were many exceptions. The scalp is known to be a favored location for distant metastasis, with approximately 5% of cases involving this site 1,3 , 34 …”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal

2004

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“…They may appear as multiple facial (Fig. 358 Histopathologically, cutaneous metastases from salivary gland carcinomas may mimic adnexal carcinoma of the skin. 357 In one case, a painful plaque of the scalp mimicking a kerion was the first sign of the salivary gland cancer.…”

Section: Cutaneous Metastases From Salivary Glandsmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

225

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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“…According to gender distribution of primary tumours, we obviously found that the 100% of patients with uterus cancer (8/ 8) 64,65,84 while in 24.8% (30/121) cases, the diagnosis was synchronous. 7,8,18,20,23,31,33,35,44,46,48,56,68,69,72,73,[76][77][78]81,84,87,93,95,96,99,102,110,111 The specific sites of primary tumours in each of these subgroups were reported in Table S1 (Supporting Information). Considering cases diagnosed after the primary tumour, they were mainly derived from breast and GI cancers (18/88 cases each); synchronous cases prevalently had a GI origin (10/30 cases), while cases diagnosed before the primary tumour were only three (one from GI, namely one thyroid and one lung cancer).…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

“…Ulceration (histologically diagnosed) was present in 31 out of 94 cases (33%), 13,15,26,[28][29][30][31]34,38,42,46,52,56,60,68,69,72,[76][77][78]80,84,92,95,97,102,106,109,114,116,117 with a higher incidence in AN related to lung cancer (4/5 cases). 68,69,72,77 The main colour of AN lesions was red-violaceous (66.7% -66/99), 2,4,6,8,9,12,13,15,17,20,21,27-29,34,40,42,43,46,47,50,53,55,57,59,61,63,65,67,68,70,71,73,75,76,78,80,83,85-89,91-93, 95-100,102,104,105,108-110,113,115-118,120,121 followed by flesh-coloured in 25.3% (25/99) 10,11,14,16,19,[23][24][25]32,33,36,45,…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Paolino

Pampena

Grassi

et al. 2019

Acad Dermatol Venereol

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Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression‐free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.

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Metastatic adenocarcinoma of the scalp mimicking a kerion

Cited by 12 publications

References 2 publications

Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal

Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal

Cutaneous Metastases From Internal Malignancies

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

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