Metastatic Basal Cell Carcinoma: Report of Two Cases and Literature Review

Ting, Patricia T.; Kasper, Richard; Arlette, John P.

doi:10.1007/s10227-005-0027-1

Cited by 111 publications

(64 citation statements)

References 32 publications

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“…Full excision with tumour-free margins is essential and there may be a need for local radiotherapy depending on tumour stage [9]. Due to the increased metastatic potential of the tumour, radiographic evaluation should be considered to fully investigate for metastases [10].…”

Section: Discussionmentioning

confidence: 99%

Basosquamous carcinoma: appearance and reality

2017

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Basosquamous carcinoma (BsC) is a controversial entity and both a diagnostic and therapeutic challenge. BsC has mixed histopathological characteristics of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC and SCC display characteristic histopathology and behaviour; on the other hand, BsC is a rare tumour, which has variable morphology and displays less predictable behaviour. An early diagnosis of BsC is important due to the particularly aggressive nature of the tumour, the increased likelihood of recurrence and the potential for metastasis. Here, we present a case of BsC presenting as an extensive ulcer on the back. The case highlights the aggressive nature of the tumour and variation in appearance. It is important for all clinicians to be aware of this diagnosis so that the urgency of adequate biopsy in specialist clinics is not underestimated.

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Section: Discussionmentioning

confidence: 99%

Basosquamous carcinoma: appearance and reality

2017

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“…Metastatic rate is <0.1%, and reported sites of metastasis are skeletal and pulmonary [6, 7]. Risk factors for metastasis are neglect over many years, perineural invasion, size over 10 cm 2 , and basisquamous and morphoeic subtypes [8].…”

Section: Introductionmentioning

confidence: 99%

Focus on Basal Cell Carcinoma

Samarasinghe

Madan

Lear

2011

Journal of Skin Cancer

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Nonmelanoma skin cancers (NMSCs), which include basal and squamous cell cancers are the most common human cancers. BCCs have a relatively low metastatic rate and slow growth and are frequently underreported. Whilst there is a definite role of sunexposure in the pathogenesis of BCC, several additional complex genotypic, phenotypic and environmental factors are contributory. The high prevalence and the frequent occurrence of multiple primary BCC in affected individuals make them an important public health problem. This has led to a substantial increase in search for newer noninvasive treatments for BCC. Surgical excision with predetermined margins remains the mainstay treatment for most BCC. Of the newer non-invasive treatments only photodynamic therapy and topical imiquimod have become established in the treatment of certain BCC subtypes, while the search for other more effective and tissue salvaging therapies continues. This paper focuses on the pathogenesis and management of BCC.

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“…Approximately, 85% of all metastatic BCC arise in the head and the neck area [12]. Bone metastases mentioned by Ting et al [13] were localized on the ribs, femoral neck and maxilla. Lymph nodes metastases have been estimated to occur in 70% of cases [2].…”

Section: Commentmentioning

confidence: 99%

Exceptional Bone Metastasis of Basal Cell Carcinoma in Gorlin-Goltz Syndrome

et al. 2009

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Background: Basal cell carcinoma (BCC), the most prevalent form of cancer worldwide, is a malignant skin neoplasm. It is locally invasive, with an exceptional incidence of reported metastasis. It can also be part of the Gorlin-Goltz syndrome, an autosomal dominant genetic disorder with high penetrance and variable expressivity, which is principally characterized by cutaneous BCC, odontogenic keratocysts, palmar and/or plantar pits, and falx cerebri calcification. Observation: We report the exceptional clinical observation of a 54-year-old man presenting bone metastasis from BCC in Gorlin-Goltz syndrome. Conclusion: Less than 300 cases of metastatic BCC have been reported in the literature. The present case is the second associated with Gorlin-Goltz syndrome.

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Metastatic Basal Cell Carcinoma: Report of Two Cases and Literature Review

Abstract: These case reports and review provide important diagnostic and management considerations for primary BCC and MBCC. Early intervention with aggressive treatment measures may improve the prognosis and survival of MBCC patients.

Cited by 111 publications

References 32 publications

Basosquamous carcinoma: appearance and reality

Basosquamous carcinoma: appearance and reality

Focus on Basal Cell Carcinoma

Exceptional Bone Metastasis of Basal Cell Carcinoma in Gorlin-Goltz Syndrome

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