Metastatic breast cancer to the thyroid diagnosed by fine-needle aspiration cytology: A case report and literature review

Yang, Zhaohui; Cai, Xiaobo; Cao, Xuequan; Zhao, Chengquan; Lu, Hongsheng

doi:10.1016/j.hpr.2022.300622

Cited by 1 publication

(1 citation statement)

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“…The vast majority of TMs are metachronous [ 20 ], detected after a mean time of 2.3 years in head and neck cancers [ 10 , 21 ], a mean time of 9.4 years in renal cell carcinoma [ 22 ], and even after 21 years in intestinal neuroendocrine tumors [ 23 ]. In our literature review, we found 38 papers published between 2000 and the end of January 2023 that satisfied our search criteria, consisting of 58 cases of TM that originated from BC [ 5 , 9 , 11 , 17 , 18 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. We summarized the cases in Table 2 .…”

Section: Current Knowledgementioning

confidence: 99%

Thyroid Metastasis from Primary Breast Cancer

Patrizio

Ferrari

Stoppini

et al. 2023

JCM

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Breast cancer (BC), the most commonly diagnosed malignancy, frequently metastasizes to the bone, lungs, brain and liver at advanced stages, whereas the thyroid gland represents a rare target site for secondary disease. We examined the most recent literature about thyroid metastasis (TM) from BC after we encountered a peculiar case of a 71-year-old woman who developed sudden dysphagia, severe hypothyroidism and hypoparathyroidism due to TM 18 years after the diagnosis of her primary cancer. Based on published data, the prevalence of TM in BC ranges from 3% to 34%, with a median onset time of 48.2 months, although longer time intervals are not infrequent. TM negatively impacts the prognosis of these patients, however thyroid surgery can limit the local disease burden. Therefore, we suggest that clinicians involved in the follow-up care of BC patients should consider a differential diagnosis of secondary thyroid malignancy when incidental lesions are diagnosed during radiological evaluations or local symptoms affect the cervical region, even many years after the diagnosis of the primary cancer.

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