Metastatic Castration-Resistant Prostate Cancer: Academic Insights and Perspectives Analysis

He, Lugeng; Fang, Hui; Chen, Chao; Wu, Yutao; Wang, Yuyong; Ge, Hongwei; Wang, Lili; He, Honghua; Wan, Yuehua

doi:10.21203/rs.2.10359/v1

Cited by 7 publications

(7 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bibliometrics is one such approach and according to Aria and Cuccurullo [ 9 ] it has the potential to perform a “systematic, transparent, and reproducible review process based on the statistical measurement of science, scientists, or scientific activity.” Various research fields make use of bibliometrics to measure the impact or influence of certain research articles. For example, in the field of engineering, the authors Bao et al [ 10 ] used bibliometric analysis to evaluate the publications in the field of robotic exoskeletons and the authors He et al [ 11 ] used bibliometrics to analyse articles related to “metastatic castration-resistant prostate cancer” in the field of health and medicine. Muhuri et al [ 12 ] projected the growth structure of the ongoing industrial revolution “Industry 4.0” using bibliometric analysis in the field of intelligent engineering [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Global Trends of Green Pesticide Research from 1994 to 2019: A Bibliometric Analysis

Smith

Idris

Maboeta

2021

Journal of Toxicology

View full text Add to dashboard Cite

The fast-growing world population places food production under enormous pressure to ensure food security. One of the most common methods to increase food production is the use of pesticides, but the continuous use thereof has numerous detrimental effects on the environment. The interest in biopesticides for a possible substitute has grown over the past two decades. To determine the research evolution of biopesticides (green pesticides), a bibliometric analysis from 1994 to 2019 was carried out. A total of 580 documents were found eligible in the Scopus database for this analysis. Parameters such as the number of articles, article citations, keywords, source impact, and countries of publication were used to analyse the documents and rank countries based on authors, productivity, article citations, and co-authorship. The analysis reveals production increased significantly from 2009 and has the most published documents in 2019 with a total of 74 articles. Asia’s most populous countries, India and China, were ranked first and second, respectively, and the USA third in terms of the most productive countries in the field of plant biopesticides. Countries in Europe and Africa however have fewer publications than expected in this field, given the fact that they are high consumers of pesticides. India, China, and the USA have 4.08%, 2.94%, and 12.5% multiple country publications (MCPs), respectively, with the USA having a stronger collaboration. Finally, there is a clear indication in this study that India and China are taking the lead in substituting synthetic pesticides with the alternative natural plant biopesticide.

show abstract

Section: Introductionmentioning

confidence: 99%

Global Trends of Green Pesticide Research from 1994 to 2019: A Bibliometric Analysis

Smith

Idris

Maboeta

2021

Journal of Toxicology

View full text Add to dashboard Cite

show abstract

“…However, in later therapeutic stage of most cases, primary resistance or adaptation by tumor cells occur associated with rising PSA levels and re-growth of tumor. Thus, the tumor eventually becomes therapy resistant, for which novel approaches and combinatorial treatments are required [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer

Kokal

Mirzakhani

Pungsrinont

et al. 2020

Cancers

View full text Add to dashboard Cite

The androgen receptor (AR) plays a leading role in the control of prostate cancer (PCa) growth. Interestingly, structurally different AR antagonists with distinct mechanisms of antagonism induce cell senescence, a mechanism that inhibits cell cycle progression, and thus seems to be a key cellular response for the treatment of PCa. Surprisingly, while physiological levels of androgens promote growth, supraphysiological androgen levels (SAL) inhibit PCa growth in an AR-dependent manner by inducing cell senescence in cancer cells. Thus, oppositional acting ligands, AR antagonists, and agonists are able to induce cellular senescence in PCa cells, as shown in cell culture model as well as ex vivo in patient tumor samples. This suggests a dual AR-signaling dependent on androgen levels that leads to the paradox of the rational to keep the AR constantly inactivated in order to treat PCa. These observations however opened the option to treat PCa patients with AR antagonists and/or with androgens at supraphysiological levels. The latter is currently used in clinical trials in so-called bipolar androgen therapy (BAT). Notably, cellular senescence is induced by AR antagonists or agonist in both androgen-dependent and castration-resistant PCa (CRPC). Pathway analysis suggests a crosstalk between AR and the non-receptor tyrosine kinase Src-Akt/PKB and the PI3K-mTOR-autophagy signaling in mediating AR-induced cellular senescence in PCa. In this review, we summarize the current knowledge of therapeutic induction and intracellular pathways of AR-mediated cellular senescence.

show abstract

“…Bibliometrics is a novel approach used to evaluate the academic achievements in a research eld through mathematical and statistical methods (12). Numbers and variations of research published in various countries, institutions and laboratories will be analyzed to explore trends and hotspots in this eld ( 13).…”

Section: Introductionmentioning

confidence: 99%

A Bibliometric Analysis of Researches on Flap Endonuclease 1 From 2005 to 2019

Wei

Shen

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in a variety of DNA metabolism processes. FEN1 is important for maintaining genomic stability and regulating cell growth and development. It is associated with the occurrence and development of several diseases, especially cancers. There is a lack of systematic bibliometric analyses focusing on research trends and knowledge structures related to FEN1.Purpose: To analyze hotspots, the current state and research frontiers performed for FEN1 over the past 15 years. Methods: Publications were retrieved from the Web of Science Core Collection (WoSCC) database, analyzing publication dates ranging from 2005 to 2019. VOSviewer1.6.15 and Citespace5.7 R1 were used to perform a bibliometric analysis in terms of countries, institutions, authors, journals and research areas related to FEN1. A total of 421 publications were included in this analysis. Results: Our findings indicated that FEN1 has received more attention and interest from researchers in the past 15 years. Institutes in the United States, specifically the Beckman Research Institute of City of Hope published the most research related to FEN1. SHEN BH，ZHENG L and BAMBARA RA were the most active researchers investigating this endonuclease and most of this research was published in the Journal of Biological Chemistry. The main scientific areas of FEN1 were related to biochemistry, molecular biology，cell biology，genetics and oncology. Research hotspots included biological activities, DNA metabolism mechanisms, protein-protein interactions and gene mutations. Research frontiers included oxidative stress, phosphorylation and tumor progression and treatment. Conclusion: This bibliometric study may aid researchers in the understanding of the knowledge base and research frontiers associated with FEN1. In addition, emerging hotspots for research can be used as the subjects of future studies.

show abstract

Metastatic Castration-Resistant Prostate Cancer: Academic Insights and Perspectives Analysis

Cited by 7 publications

References 91 publications

Global Trends of Green Pesticide Research from 1994 to 2019: A Bibliometric Analysis

Global Trends of Green Pesticide Research from 1994 to 2019: A Bibliometric Analysis

Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer

A Bibliometric Analysis of Researches on Flap Endonuclease 1 From 2005 to 2019

Contact Info

Product

Resources

About