Metastatic crohn's disease

Metastatic Crohn's disease is a rare skin manifestation, defined by granulomatous skin lesions that are discontinuous to the affected gastrointestinal tract and histopathologically resembling inflammatory bowel lesions. Up to 44% of patients with Crohn's disease have cutaneous manifestations, of which metastatic lesions are the least common. We present a case of an adolescent with refractory Crohn's disease and persistent papules and plaques on the skin.

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“…The use of other immunosuppressant's drugs, thalidomide, surgery, and topic tacrolimus has also been reported. 2,8 …”

Section: Discussionmentioning

confidence: 99%

Case for diagnosis. Metastatic Crohn's disease

Gontijo

Leidenz

Sousa

2016

An. Bras. Dermatol.

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“…A predisposition of these lesions to moist environments such as intertriginous and flexural areas has been documented in the literature [17]. MCD affects both sexes and all ages equally [10, 12].…”

Section: Clinical Presentationmentioning

confidence: 99%

Metastatic Crohn’s Disease: An Approach to an Uncommon but Important Cutaneous Disorder

Aberumand

Howard

2017

BioMed Research International

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Objective. To provide physicians with a clinical approach to metastatic Crohn's disease (MCD). Main Message. Metastatic Crohn's disease, defined as skin lesions present in areas noncontiguous with the gastrointestinal tract, is the rarest cutaneous manifestation of Crohn's disease. MCD lesions vary in morphology and can arise anywhere on the skin. MCD presents equally in both sexes and across age groups. Cutaneous findings may precede, develop concurrently with, or follow gastrointestinal involvement. A detailed history and thorough physical examination including a full-skin exam may help to exclude other dermatoses, as MCD can mimic other common disorders. A biopsy is required for a definitive diagnosis. Treatment options for MCD remain underwhelming due to the lack of randomized control studies and varying responses of reported therapeutic methods. Topical, intralesional, and systemic corticosteroids, antibiotics, traditional immunosuppressants, and surgery have shown mixed results. Recently, biologics have shown promise, even with refractory cases of MCD. Conclusion. MCD is an important cutaneous manifestation of this inflammatory disorder. Although a rare entity, early recognition can provide opportunity for successful therapeutic intervention.

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“…It usually presents as cutaneous ulcerations, but plaques, papules, and nodules have also been described [7]. Lesions often have a predilection for the skin folds or limbs and are notoriously difficult to heal [1,2]. There appears to be no distinct relation between the presence of these lesions and active intestinal disease [3][4][5].…”

Section: Discussionmentioning

confidence: 91%

“…Some studies suggest that metastatic Crohn's disease occurs more often in patients that have colonic involvement [9]. Biopsies of these lesions will reveal multinucleated giant cells and noncaseating granulomas [1]. Other histopathologic features include perivascular lymphocytes, monocytes, and necrobiosis [10][11][12].…”

Section: Discussionmentioning

confidence: 99%