Metastatic gastric cancer of the testis diagnosed through urine cytology

Gastric‐type adenocarcinoma of the uterine cervix presenting in urine cytology specimens: A case report and literature review

“…10 When distinguishing the secondary involvement of gastric phenotype cancer from primary urothelial cancer in urinary cytology, abundant and vacuolated cytoplasm can be helpful for diagnosing cancer of gastric phenotype; however, this finding is limited in cases with poorly-differentiated cells. 13 This case was unique in that GEA was first observed by urinary cytology, and that cytological findings were somewhat different from the low-grade features observed previously in extremely welldifferentiated GEA. It is important for pathologists to recognize the broad cytological and morphological spectra of GEA, and the fact that it can represent one of the differential diagnoses for glandular neoplasms of non-urothelial origin on urinary cytology.…”

“…If many abnormal glandular cells are observed, immunohistochemical staining with GATA3 and PAX8 using a cell block may be helpful for finding the primary site 10 . When distinguishing the secondary involvement of gastric phenotype cancer from primary urothelial cancer in urinary cytology, abundant and vacuolated cytoplasm can be helpful for diagnosing cancer of gastric phenotype; however, this finding is limited in cases with poorly‐differentiated cells 13 …”

An Approach to Nonurothelial Malignancies of the Urinary Bladder in Urine Cytology

“…39 Due to the low incidence of metastasis to the bladder, there is limited literature focused on cytologic findings of metastatic lesions in urine specimens. 28,[40][41][42][43][44] One of the most common sources of secondary malignancy identified in urine cytology is the prostate, as advanced prostatic ADCs can involve the bladder neck or prostatic urethra and subsequently shed malignant cells into the urine. Malignant cells of prostatic ADC have been described as having high N:C ratios, round to ovoid nuclei, fine chromatin distribution, and characteristically conspicuous nucleoli and being arranged in cohesive acini and/or syncytial clusters in urine specimens.…”

“…In each of these cases, there was a known history of malignancy in these sites, preempting further evaluation for the involvement of the bladder by metastatic disease either with the help of IHC, comparison of morphology with prior histology, or clinicoradiologic correlation 39. Due to the low incidence of metastasis to the bladder, there is limited literature focused on cytologic findings of metastatic lesions in urine specimens 28,40–44. One of the most common sources of secondary malignancy identified in urine cytology is the prostate, as advanced prostatic ADCs can involve the bladder neck or prostatic urethra and subsequently shed malignant cells into the urine.…”