Metastatic melanoma: Chemotherapy

Bajetta, Emilio; Vecchio, Michele Del; Bernard-Marty, Chantal; Vitali, Milena; Buzzoni, Roberto; Rixe, Olivier; Nova, P.; Aglione, Stefania; Taillibert, Sophie; Khayat, David

doi:10.1053/sonc.2002.35238

Cited by 149 publications

(116 citation statements)

References 91 publications

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“…The median survival time is approximately 7 mo, with a 5-y survival of 5% in stage IV (19), due to melanoma's resistance to standard chemotherapy (20). Surgical excision remains the best treatment option (21), though standard immunotherapy shows a moderate success in metastatic melanoma treatment (22,23).…”

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confidence: 99%

Fine analysis of spontaneous MAGE-C1/CT7–specific immunity in melanoma patients

Nuber

Curioni-Fontecedro

Matter

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Cancer/testis (CT) antigens represent prime candidates for immunotherapy in cancer patients, because their expression is restricted to cancer cells and germ cells of the testis. MAGE-C1/CT7 is a CT antigen that is highly expressed in several types of cancers. Spontaneous occurrence of CT7-specific antibodies was previously detected by SEREX screen in a melanoma patient. However, naturally occurring CT7-specific T-cell responses have thus far not been detected. Peripheral blood mononuclear cells (PBMCs) from 26 metastatic melanoma patients expressing CT7 in their tumor lesions (CT7 + ) were analyzed for CT7-specific T-cell responses using overlapping peptides. CT7-specific CD4 + T-cell responses were detected in three patients (11.5%). These CT7-specific CD4 + T-cell responses were detectable in melanoma patients' PBMCs exclusively from preexisting CD45RA − memory CD4 + T-cell pool. Additional CT7-specific memory CD4 + T-cell responses were detected in CT7 + melanoma patients after depletion of CD4 + CD25high Treg cells showing that Treg cells impact on CT7-specific CD4 + T cells in melanoma patients. CT7-specific CD4 + T-cell clones were generated and used to define minimal epitopes, restriction elements, and confirm the recognition of naturally processed antigen. Surprisingly, these clones were able to secrete perforin and exert cytotoxicity. This study shows that CT7 can induce specific cellular immunity in melanoma patients. Based on these findings, CT7 will be further explored as a potential vaccine for melanoma immunotherapy.cancer/testis antigens | T-cell response

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mentioning

confidence: 99%

Fine analysis of spontaneous MAGE-C1/CT7–specific immunity in melanoma patients

Nuber

Curioni-Fontecedro

Matter

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…It has been reported that the median survival time of stage IV melanoma patients is about 6 -7.5 months, the 5-year survival rate being approximately 6% (Bajetta et al, 2002). Lung metastasis of melanoma cells from primary lesions is an especially important factor influencing the prognosis of patients.…”

Section: Discussionmentioning

confidence: 99%

“…Various anticancer drugs, including bleomycin, VCR, lomustine and dacarbazine, have been used in recent years for treating patients with melanoma (Wöll et al, 1999;Kivela et al, 2003). However, severe side effects of the chemotherapeutic agents have limited the application of high-dose chemotherapy or combination therapy with different anticancer drugs for many cases of malignant melanoma (Bajetta et al, 2002). Combinational treatment with different drugs that induce different cell cycle arrest results in apoptosis in tumour cells (Darzynkiewicz, 1986;Bhuyan and Groppi, 1989;Ko et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice

et al. 2004

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We examined the antitumour effect of a combination of betulinic acid (BA) and vincristine (VCR) on murine melanoma B16F10 cells in vitro and in vivo. Betulinic acid, a pentacyclic triterpene, showed a synergistic cytotoxic effect on melanoma cells by combinational use of VCR. Betulinic acid and VCR induced cell cycle arrest at different points (BA at G1 phase and VCR at G2/M phase) and caused apoptosis in B16F10 melanoma cells. In the in vivo study, VCR inhibited metastasis of tumour cells to the lung. The addition of BA to VCR augmented suppression of the experimental lung metastasis of melanoma cells in C57BL/6 mice. The number of lung nodules of more than 1 mm in diameter in mice treated with BA and VCR was less than that in mice treated with VCR alone. These results suggest that BA is an effective supplement for enhancing the chemotherapeutic effect on malignant melanoma.

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“…3,4 In the present case, combinations of all these methods were successfully used to evaluate the patient's condition.…”

Section: Discussionmentioning

confidence: 99%

Prolonged survival after surgical resection of cerebral metastasis from melanoma with multisystemic metastasis already present: a case report and literature review

2017

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CONTEXT: Malignant melanoma is the third most common cause of cerebral metastases after breast and lung cancer. Despite advances in therapeutic options, the prognosis for patients with cerebral metastases from melanoma remains poor, with a median survival time of six months after diagnosis. CASE REPORT: A 65-year-old woman was diagnosed with a malignant melanoma on the third toe of her left foot. The tumorous spot was excised surgically. However, the melanoma reappeared after one year and skin biopsy confirmed recurrence of malignant melanoma. Investigations showed metastasis to the left pelvic region, left lobe of the liver and right lobe of the lung. The patient then received chemotherapy. Subsequently, the patient was brought to the emergency department with an altered level of consciousness (Glasgow coma scale: 9) and hemiplegia on the right side of her body. Computed tomography scans of the brain revealed hemorrhagic lesions in the parieto-occipital lobes of the brain. Urgent surgical evacuation was done to remove the lesion, following which the patient showed improvement in her score on the Glasgow coma scale and a concomitant decrease in weakness. She was discharged from hospital with full consciousness. The patient died of acute renal failure 14 months after the brain surgery and approximately 4 years after the initial presentation of the case. CONCLUSION: This case outcome is rare and shows the effectiveness of surgery to treat cerebral metastasis from malignant melanoma in a situation with multisystem metastasis already present.

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Metastatic melanoma: Chemotherapy

Cited by 149 publications

References 91 publications

Fine analysis of spontaneous MAGE-C1/CT7–specific immunity in melanoma patients

Fine analysis of spontaneous MAGE-C1/CT7–specific immunity in melanoma patients

Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice

Prolonged survival after surgical resection of cerebral metastasis from melanoma with multisystemic metastasis already present: a case report and literature review

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