Metastatic melanoma of the stomach

Abstract

BACKGROUND: Metastatic melanoma of the stomach is a relatively rare entity with an unusual diagnosis during life. Surgery is the treatment of choice once it alleviates the symptoms in over 90% of the cases and increases the long-term survival. CASE REPORT: A 50y woman had presented a dark spot in the ungual bed of her right-hand thumb for two years, evolving into ulceration and bleeding. The biopsy diagnosed ungual malanocytic neoplasia compatible with lentiginous melanoma confirmed by immunohistochemistry, which presented positive pigmented HMB-45 cells. After an year and a half, the patient developed metastasis of the melanoma on her left thigh and extensive ulcerated lesion in the small gastric curvature, whose biopsy was compatible with metastatic melanoma of the stomach. The hemogram found discrete anemia (Hb: 11.1 and Ht: 33%) and LDH: 333 U/L. The patient underwent total gastrectomy with reconstruction in Roux-en-Y. There was a good evolution and on the 6th post-operative day, she was discharged home. At present, in the 12th month of follow up, the patient remains without complaints, with full relief of symptoms and all normal control exams. CONCLUSION: Surgical management should always be considered for the metastatic melanoma of the gastrointestinal tract, since the procedure shows low morbidity and mortality, besides providing relief of symptoms with the improvement of the quality of life and increase in the long-term survival.

A Case of Treated Penile Melanoma with Gastric Recurrence

“…Other exams such as upper endoscopy, colonoscopy, and CT are repeated as clinically indicated. 20 Secondary gastric melanomas are usually diagnosed at the time of autopsy. 7,8 This case depicts a rare case of penile melanoma, which was resected and underwent chemotherapy; however, it presented 3 years post-operatively with tests showing isolated gastric recurrence.…”

Multiple cutaneous melanomas associated with gastric and brain metastases

“…Clinical picture includes anemia, abdominal pain, weight loss, apparent or occult gastrointestinal bleeding, and abdominal mass. 6 Approximately 60% of patients who die of melanoma have gastrointestinal metastases identified by autopsy. 6 The most common sites in descending order are: small intestine, colon, and stomach, the latter is affected by 5-7% of cases.…”

“… 6 Approximately 60% of patients who die of melanoma have gastrointestinal metastases identified by autopsy. 6 The most common sites in descending order are: small intestine, colon, and stomach, the latter is affected by 5-7% of cases. 6 Moreover, brain metastases are common in individuals with melanoma.…”

“… 6 The most common sites in descending order are: small intestine, colon, and stomach, the latter is affected by 5-7% of cases. 6 Moreover, brain metastases are common in individuals with melanoma. 7 Among the solid tumors, melanoma is a major risk factor for the development of brain metastases which occur in about 40% of the patients with advanced stages of the disease.…”

Gastric metastases of a malignant melanoma

“…Malignant melanoma is a malignant melanocytic cell tumor of the skin, responsible for about 5% of all malignancies in this organ 1,2 . The incidence increases proportionally with age, presenting a higher prevalence between the fifth and seventh decade of life, affecting men and women indiscriminately.…”