Metastatic Melanotic Neuroectodermal Tumor of Infancy: Report of a Case and Review of the Literature

Azarisamani, Amir; Petrisor, Daniel; Wright, John M.; Ghali, Ghali E.

doi:10.1016/j.joms.2016.05.028

Cited by 19 publications

(43 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although we found that MNTI of the jaw bones has a good prognosis, 3,23,24 patients should be followed-up due to the possibility of recurrence or metastasis; after 20 and 12 months, respectively, the orbit was the site most affected by distant metastasis. Azarisamani and collaborators 23 observed that tumors in the jaws that metastasized to regional lymph nodes led to death due to disease, which is consistent with our results, as all affected patients died. Previous studies showed that younger patients had a better prognosis than older patients.…”

Section: Discussionsupporting

confidence: 92%

“…3,8,18,23 Nevertheless, according to our analysis, they are important survival factors, as the odds ratio of death among patients who presented recurrence was 55 times higher than in patients who did not present recurrence. 3,8,18,23 Nevertheless, according to our analysis, they are important survival factors, as the odds ratio of death among patients who presented recurrence was 55 times higher than in patients who did not present recurrence.…”

Section: Discussionmentioning

confidence: 67%

“…Abbreviations: +M, presence of metastasis; −M, absence of metastasis; +R, presence of recurrence; −R, absence of recurrence; CS, conservative surgery (complete excision); CT, chemotherapy; LNM, lymph node metastasis; RS, radical surgery; RT, radiotherapy [Color figure can be viewed at wileyonlinelibrary.com] the disease. Although we found that MNTI of the jaw bones has a good prognosis, 3,23,24 patients should be followed-up due to the possibility of recurrence or metastasis; after 20 and 12 months, respectively, the orbit was the site most affected by distant metastasis. 3,8,18,23 Our study found that age is a significant prognostic factor.…”

Section: Discussionmentioning

confidence: 72%

“…Although we found that MNTI of the jaw bones has a good prognosis, 3,23,24 patients should be followed-up due to the possibility of recurrence or metastasis; after 20 and 12 months, respectively, the orbit was the site most affected by distant metastasis. 3,8,18,23 Our study found that age is a significant prognostic factor. Previous studies showed that younger patients had a better prognosis than older patients.…”

Section: Discussionmentioning

confidence: 72%

“…1,11,14,23 Our analysis demonstrated that surgery (complete excision and radical surgery) is important to reduce the possibility of recurrence. Our findings are consistent with those of other studies, which found that surgical treatment is essential for a good prognosis over long-term follow-up.…”

Section: Discussionmentioning

confidence: 90%

See 4 more Smart Citations

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

et al. 2018

View full text Add to dashboard Cite

The aim of the present study was to integrate the available data published on melanotic neuroectodermal tumor of infancy (MNTI) of the jaw bones. An electronic search was undertaken in April 2018. Hundred forty‐seven publications and 371 patients were included. The lesion was more prevalent in males and in the second to sixth months of life. The lesions mostly presented as a rapidly growing bluish swelling and the most commonly involved was the anterior maxilla. The mean follow‐up was 51.1 months (range 1‐408 months). Age (P ≤ .0001), location (P = .007), occurrence of lymph node metastasis (P ≤ .0001), treatment (P = .001), recurrence (P ≤ .0001), and distant metastasis (P = .0001) were independently associated with survival. Recurrence was significantly correlated with age (P = .0001), distant metastasis (P = .0001), and treatment (P = .0001). Patients older than 12 months, with lesions in the mandible, positive regional lymph node metastasis, treated with chemotherapy, recurrence, or distant metastasis presented the worst prognosis.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 72%

“…Although we found that MNTI of the jaw bones has a good prognosis, 3,23,24 patients should be followed-up due to the possibility of recurrence or metastasis; after 20 and 12 months, respectively, the orbit was the site most affected by distant metastasis. 3,8,18,23 Our study found that age is a significant prognostic factor. Previous studies showed that younger patients had a better prognosis than older patients.…”

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 90%

See 3 more Smart Citations

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

et al. 2018

View full text Add to dashboard Cite

show abstract

Clinical and imaging features of melanotic neuro-ectodermal tumor of infancy of the maxillary bone: report of four cases and review of the literature

et al. 2022

View full text Add to dashboard Cite

Melanotic neuro-ectodermal tumor of infancy (MNTI) is an extremely rare tumor. The purpose of this study was to describe the imaging features of maxillary bone MNTIs and introduce the key points for clinical diagnosis of MNTI. We retrospectively reviewed four patients with histology-proven MNTIs arising from the maxillary bone. All patients underwent ultrasonic inspections, CT and/or MR scanning. Combined with previously literature, the imaging features were comprehensively evaluated and analyzed. All MNTIs showed a firm, non-ulcerated rapidly-growing soft-tissue swelling with pigmented (blue-colored or black-colored or gray-colored) mucosa. The onset ages were younger than 6 month-old. CT images showed osteolytic or expansive bone destruction of the involved maxillae, fragmentary cortical bone, “free-floating” tooth germs, with or without spiculated/sunburst periosteal reaction. The tumor appeared lightly hyper-intense on T2-weighted sequences, while isointense or lightly hypo-intense or lightly hyper-intense signal on T1-weighted sequences. Enhanced images all displayed heterogeneous enhancement. No metastasis features of lymph nodes or abdominal organs were demonstrated by cervical and abdominal ultrasonic inspections. As a conclusion, accurate recognition of the imaging features of MNTI combined with history and clinical manifestations (early infancy, painless, firm, pigmented mucosa, non-ulcerating lesion) can provide clues for diagnosis of this rare entity.

show abstract

Black and Brown Oro-facial Mucocutaneous Neoplasms

Natarajan

2019

Head and Neck Pathol

View full text Add to dashboard Cite

Black and brown-colored mucocutaneous lesions present a differential diagnostic challenge, with malignant melanoma being the primary clinical concern. The vast majority of pigmented lesions in the head and neck region are the result of benign, reactive factors such as post-inflammatory melanosis. However, it is not uncommon to discover a range of muco-cutaneous black and brown neoplasms in the oro-facial area. The majority of black/brown pigmented neoplasms are melanocytic in origin; these are neoplasms of neural crest derivation. Melanocytic nevi are a diverse group of benign neoplasms that are the result of specific oncogenic mutations. They are common on cutaneous surfaces but can manifest in mucosal sites. Currently, nevi are classified based on clinical and histological criteria. The most common cutaneous and oral mucosal nevus is the acquired melanocytic nevus; nevi do not pose an increased risk for the development of malignant melanoma. Emerging information on specific genetic differences supports the notion of biologically distinct nevi. This article will review the classic clinical and microscopic features of nevi commonly found in the head and neck region, and discuss emerging concepts in nevus pathogenesis and taxonomy. Melanoma is a malignant melanocytic neoplasm and is a result of cumulative genetic deregulation. The etiology of malignant melanoma (MM) is multifactorial and includes underlying genetic susceptibility, UV radiation, skin-type, and race. The majority of MM occurs on cutaneous surfaces and less commonly on mucosal and extra-cutaneous visceral organs. Regardless of location, MM exhibits clinical-pathological features that relate to horizontal or vertical tumor spread. Cutaneous and mucosal MM typically present as asymmetrical, irregularly bordered, large (> 0.5 cm), heterogeneous brown-black lesions with foci of erythema, atrophy or ulceration. As with melanocytic nevi, advances in melanomagenesis research have revealed primary oncogenic BRAF and NRAS mutations associated with cutaneous MM. Unlike their cutaneous counterparts, mucosal melanomas exhibit primary oncogenic alterations in c-KIT and other genes. This article will discuss the role of specific primary oncogenic and secondary/tertiary genetic defects in differential clinical presentation, anatomic distribution, future classification changes, and targeted therapy of melanoma. The clinical and microscopic features of mucosal melanomas and a summary of management guidelines will be discussed. Additionally, this article will cover the salient features of melanocytic neuroectodermal tumor of infancy, a neoplastic entity that can involve the oro-facial region, and the clinical-pathological features of selected, commonly occurring pigmented ectodermally-derived neoplasms that are often part of the clinical differential diagnosis of black-brown pigmented lesions.

show abstract

Metastatic Melanotic Neuroectodermal Tumor of Infancy: Report of a Case and Review of the Literature

Cited by 19 publications

References 34 publications

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

Clinical and imaging features of melanotic neuro-ectodermal tumor of infancy of the maxillary bone: report of four cases and review of the literature

Black and Brown Oro-facial Mucocutaneous Neoplasms

Contact Info

Product

Resources

About