Metastatic Myocardial Calcification in Chronic Renal Failure Presenting as Atrioventricular Block

Henderson, Robert R.; Santiago, Lombardo M.; Spring, Donald A.; Harrington, Avery R.

doi:10.1056/nejm197106032842208

Cited by 27 publications

(12 citation statements)

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“…Secondary hyperparathyroidism is one of the major complications of patients in renal failure undergoing maintenance hemodialysis and has caused fatalities [6]. Calcitonin has been used successfully to counteract increased skeletal turnover in Paget's disease [4,7,8] and in this disease reduces the increased serum alkaline phosphatase levels, hydroxyprolinuria, accelerated skeletal turnover of radiocalcium and increased bone collagenase activity [9] which are characteristic of the disease.…”

Section: Discussionmentioning

confidence: 99%

A Trial of Calcitonin Therapy in Renal Osteodystrophy

Delano¹,

Baker²,

Gardner³

et al. 1973

Nephron

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Synthetic salmon calcitonin (100 MRC units/day)was administered to three patients with chronic renal insufficiency supported by maintenance hemodialysis; these patients had also developed secondary hyperparathyroidism.The diagnosis of hyperparathyroidism was based on bone pain, X-ray changesindicating subperiosteal bone reabsorption, increased levels of serum alkaline phosphatase, accelerated radiocalcium turnover, increased resorption on bone biopsy and increased levels of bone cell collagenase activity. No improvement was noted in any of the measured parameters after 4–11 weeks of calcitonin therapy. A further increase in serum alkaline phosphatase occurred in one patient and bone cell collagenase activity increased further in all three patients. These data suggest that calcitonin may exaggerate the secondary hyperparathyroidism of chronic renal failure and, therefore, is not therapeutically useful.

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Section: Discussionmentioning

confidence: 99%

A Trial of Calcitonin Therapy in Renal Osteodystrophy

Delano¹,

Baker²,

Gardner³

et al. 1973

Nephron

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“…Infiltrative diffuse myocardial calcifications are rare findings; they can be associated with ventricular wall motion abnormalities, present as restrictive cardiomyopathy, and can be associated with sudden cardiac death ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

Stone Heart

et al. 2021

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“…Moreover, no drug with negative chronotropic or dromotropic effects was associated to the verapamil and there was no other electrolyte abnormality with the exception of acidosis and no evidence for tissue underperfusion. Atrioventricular conduction defects among uremic patients have also been attributed to extensive metastatic calcifications, 9 consecutive to elevated calcium‐phosphate product. Actually, one patient (Case 1) exhibited aortic and mitral valve calcifications.…”

Section: Discussionmentioning

confidence: 99%

Verapamil and mild hyperkalemia in hemodialysis patients: A potentially hazardous association

Letavernier

Couzi

Delmas

et al. 2006

Hemodialysis International

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During the past 3 years, 3 patients undergoing intermittent hemodialysis (or about to do so) in our hospital developed a third-degree atrioventricular block while being treated with verapamil for blood pressure or supraventricular arrhythmia. In the 3 cases, mild hyperkalemia was concomitant. The medical history of these patients revealed no intrinsic cause of atrioventricular conduction disturbance. We report herein the 3 cases and draw attention to the risks of atrioventricular block in this particular context.

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Metastatic Myocardial Calcification in Chronic Renal Failure Presenting as Atrioventricular Block

Cited by 27 publications

References 0 publications

A Trial of Calcitonin Therapy in Renal Osteodystrophy

A Trial of Calcitonin Therapy in Renal Osteodystrophy

Stone Heart

Verapamil and mild hyperkalemia in hemodialysis patients: A potentially hazardous association

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