Metastatic Spread from Abdominal Tumor Cells to Parathymic Lymph Nodes

Király, Gábor; Hargitai, Zoltán; Kovács, Ilona; Szemán-Nagy, Gábor; Juhász, István; Bánfalvi, Gáspár

doi:10.1007/s12253-018-0492-7

Cited by 2 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Resultsmentioning

confidence: 99%

“…These experiments aimed to investigate the short-term biodistribution of FSGM in order to determine their applicability as vehicles for antimetastatic drugs. Furthermore, the parathymical metastasis mouse model used in the related study required a 3 weeks interval of treatment [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

“…The results showed that ink particles traversed the diaphragm and accumulated in the cortical part of the parathymic lymph nodes. It was also shown that metastatic cancer cells followed the same route, most probably via lymphatic circulation [14]. In order to obtain qualitative information on the distribution of FSGM, we used fluorescence microscopy and immunohistochemical staining.…”

Section: Biodistribution Of Aerogel Microparticlesmentioning

confidence: 99%

“…The application of this image processing method for every other tissue sample verified that neither the liver, nor the spleen, nor the kidney contained FSGM, only the thymus. metastatic cancer cells followed the same route, most probably via lymphatic circulation [14].…”

Section: Biodistribution Of Aerogel Microparticlesmentioning

confidence: 99%

“…injection. For example, microparticles injected into the abdominal cavity could possibly follow abdominal tumor cells that metastasize to the parathymic lymph nodes via the lymphatic circulation, providing passively targeted drug delivery [ 12 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Mesoporous Aerogel Microparticles Injected into the Abdominal Cavity of Mice Accumulate in Parathymic Lymph Nodes

Király

Egu

Hargitai

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Mesoporous aerogel microparticles are promising drug delivery systems. However, their in vivo biodistribution pathways and health effects are unknown. Suspensions of fluorescein-labeled silica–gelatin hybrid aerogel microparticles were injected into the peritoneum (abdominal cavity) of healthy mice in concentrations of 52 and 104 mg kg−1 in a 3-week-long acute toxicity experiment. No physiological dysfunctions were detected, and all mice were healthy. An autopsy revealed that the aerogel microparticles were not present at the site of injection in the abdominal cavity at the end of the experiment. The histological study of the liver, spleen, kidneys, thymus and lymphatic tissues showed no signs of toxicity. The localization of the aerogel microparticles in the organs was studied by fluorescence microscopy. Aerogel microparticles were not detected in any of the abdominal organs, but they were clearly visible in the cortical part of the parathymic lymph nodes, where they accumulated. The accumulation of aerogel microparticles in parathymic lymph nodes in combination with their absence in the reticuloendothelial system organs, such as the liver or spleen, suggests that the microparticles entered the lymphatic circulation. This biodistribution pathway could be exploited to design passive targeting drug delivery systems for flooding metastatic pathways of abdominal cancers that spread via the lymphatic circulation.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Biodistribution Of Aerogel Microparticlesmentioning

confidence: 99%

Section: Biodistribution Of Aerogel Microparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mesoporous Aerogel Microparticles Injected into the Abdominal Cavity of Mice Accumulate in Parathymic Lymph Nodes

Király

Egu

Hargitai

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Apoptotic Janus-faced mycotoxins against thoracal and breast metastases

Bánfalvi

2023

Apoptosis

View full text Add to dashboard Cite

Abdominal organs (liver, kidney, spleen) are frequent targets of cancer cell invasion but their primary tumours are less known for their metastatic potential to other organs e.g. to the breast. Despite the known connection of the pathogenesis from breast cancer to liver metastasis, the study of the spread in the opposite direction has been neglected. The notion that breast cancer could be a metastasis besides being a primary tumour is based on rodents’ tumour models upon implantation of tumour cells under the capsule of the kidney or under the Glisson’s capsule of the liver of rats and mice. Tumour cells develop into a primary tumour at the site of subcutaneous implantation. The metastatic process starts with peripheral disruptions of blood vessels near the surface of primary tumours. Tumour cells released into the abdomen cross the apertures of the diaphragm, enter the thoracal lymph nodes and accumulate in parathymic lymph nodes. Abdominal colloidal carbon particles injected into the abdomen faithfully mimicked the migration of tumour cells and deposited in parathymic lymph nodes (PTNs). An explanation is provided why the connection between abdominal tumours and mammary tumours escaped attention, notably, parathymic lymph nodes in humans were referred to as internal mammary or parasternal lymph nodes. The apoptotic effect of Janus-faced cytotoxins is suggested to provide a new approach against the spread of abdominal primary tumours, and metastatic development.

show abstract

Metastatic Spread from Abdominal Tumor Cells to Parathymic Lymph Nodes

Cited by 2 publications

References 22 publications

Mesoporous Aerogel Microparticles Injected into the Abdominal Cavity of Mice Accumulate in Parathymic Lymph Nodes

Mesoporous Aerogel Microparticles Injected into the Abdominal Cavity of Mice Accumulate in Parathymic Lymph Nodes

Apoptotic Janus-faced mycotoxins against thoracal and breast metastases

Contact Info

Product

Resources

About