Metastatic spread of systemic neoplasms to central nervous system tumors: review of the literature and case presentation of esophageal carcinoma metastatic to meningioma

Richter, Bertram; Harinath, Lakshmi; Pu, Cunfeng; Stabingas, Kristen

doi:10.5414/np300980

Cited by 14 publications

(9 citation statements)

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“…There are several criteria to diagnose TTM and differentiate it from a collision tumor ( Tables 1 and 2 ) [ 8 9 ]. According to Campbell et al [ 8 ], TTM can be diagnosed when the following conditions are satisfied: 1) coexistence of two or more primary tumors; 2) the host tumor must be a true neoplasm; 3) histologically different tumor tissue must enclose the metastatic focus, not be of contiguous growth, with the absence of an intermediate transitional zone; and 4) extravascular metastasis must be present with the exclusion of metastasis to the lymphatic system (such as lymphoma) where the second primary tumor is present with an active hematologic malignancy ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Breast Cancer to Meningioma: A Rare Case of Tumor-to-Tumor Metastasis

Joe

Lee

Kim

et al. 2023

Brain Tumor Res Treat

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Tumor-to-tumor metastasis (TTM) is defined as the hematogenous metastasis within a primary host tumor from a donor neoplasm. Since there is insufficient evidence regarding the pathophysiology, clinical course, and management of TTM, there are no precise guidelines for its management. A 73-year-old female patient diagnosed with breast cancer was found to have convexity meningioma. Since the size of tumor and peritumoral brain edema increased during follow-up period, the meningioma was treated with surgical resection. Postoperatively, histopathologic examination confirmed metastasis of invasive ductal carcinoma within a secretory meningioma. The final diagnosis was TTM of breast cancer in meningioma. Here, we report a rare case of intra-meningioma metastasis and a review of literature to provide a better understanding of this rare phenomenon.

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Section: Discussionmentioning

confidence: 99%

Breast Cancer to Meningioma: A Rare Case of Tumor-to-Tumor Metastasis

Joe

Lee

Kim

et al. 2023

Brain Tumor Res Treat

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“… 2 Research has also suggested that high vascularity and locations of recipient sites play a role in the process of a metastasis situating itself within another tumour. 3 This is known as the “mechanical theory”.…”

Section: Discussionmentioning

confidence: 99%

Oesophageal adenocarcinoma metastasis into a microcystic meningioma: a rare occurrence of tumour to tumour metastasis

2022

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A 78 year old male was admitted with a history of a fall following seizures. This occurred 2 years post curative treatment (minimally invasive oesophagectomy with neo adjuvant chemotherapy) for an oesophageal adenocarcinoma staged T3N0M0. On examination, patient had left-sided hemiparesis. A Computed Tomography (CT) and Magnetic Resonance Image (MRI) of the head confirmed a right frontotemporal meningioma with features suggestive of internal haemorrhage or calcification and mild local mass effect. A joint decision was made between the local neuro-surgical and neurology departments to manage this conservatively. However, due to progressive neurological deterioration and a concomitant increase in the size of the haemorrhagic lesion, emergent surgical intervention was indicated. The patient underwent a Simpson one complete resection (complete tumour resection including associated dura matter and abnormal underlying bone). Postoperative histology confirmed a rare case of metastatic oesophageal adenocarcinoma to a microcystic meningioma (World Health Organization Grade I). The meningioma was the only known site of distant metastasis for the oesophageal adenocarcinoma. Our case highlights the only documented case of the adenocarcinoma subtype of oesophageal tumour metastasizing to a meningioma. This case demonstrates the rare but well documented occurrence of tumour to tumour metastasis. It highlights the importance played by imaging and clinical correlation when assessing progressively growing meningiomas in patients with a history of or underlying malignancy.

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“…2 , 10 , 11) The majority of metastases arise from lung or breast carcinomas. 10 , 12 , 13) Other types of benign intracranial tumors, such as schwannoma and pituitary adenoma, have rarely been reported. 12) Contrastingly, RCC-to-hemangioblastoma is the most common donor–recipient tumor association among tumor-to-tumor metastasis cases.…”

Section: Discussionmentioning

confidence: 99%

Metastasis of Renal Cell Carcinoma to Spinal Hemangioblastoma in a Patient with von Hippel–Lindau Disease: A Case Report

Wakita

Tamiya

Higuchi

et al. 2021

NMC Case Report Journal

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von Hippel-Lindau (VHL) disease is characterized by neoplastic and cystic lesions, such as central nervous system (CNS) hemangioblastoma and clear cell renal cell carcinoma (RCC), arising in multiple organs. Here, we report a case of an RCC that metastasized to a spinal hemangioblastoma in a patient diagnosed with VHL disease. This is a unique case study because visceral neoplasms rarely metastasize to the CNS. The patient had undergone posterior fossa surgery for the removal of hemangioblastomas in the right cerebellar hemisphere as a child. He was diagnosed with RCC at the age of 20 years, and he underwent partial nephrectomy at the age of 35 years. The patient underwent surgical removal of a spinal tumor from Th8, which was also diagnosed as a hemangioblastoma at the age of 40. However, the residual spinal tumor rapidly regrew within 1.5 years. A second surgery was performed due to progressive leg motor weakness. The resected tumor from the second surgery had two distinct components between the tumor center and the margin. Immunohistochemistry of CD10, PAX 8, and inhibin A demonstrated the predominant region of the tumor was RCC. Pathological findings confirmed tumor-to-tumor metastasis of the RCC migrating into residual spinal hemangioblastoma. It can be challenging to distinguish hemangioblastoma from RCC in neuroimaging. We suggest that tumor-to-tumor metastasis should be considered as a differential diagnosis if benign tumors grow rapidly, even if the pathological diagnosis does not initially confirm malignancy. The biological mechanisms of RCC migrating into residual hemangioblastoma are discussed.

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Metastatic spread of systemic neoplasms to central nervous system tumors: review of the literature and case presentation of esophageal carcinoma metastatic to meningioma

Cited by 14 publications

References 0 publications

Breast Cancer to Meningioma: A Rare Case of Tumor-to-Tumor Metastasis

Breast Cancer to Meningioma: A Rare Case of Tumor-to-Tumor Metastasis

Oesophageal adenocarcinoma metastasis into a microcystic meningioma: a rare occurrence of tumour to tumour metastasis

Metastasis of Renal Cell Carcinoma to Spinal Hemangioblastoma in a Patient with von Hippel–Lindau Disease: A Case Report

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