Metastatic thyroid carcinoma to the mandible

Hallikeri, Kaverı; Punnya, V.A.; Tayaar, Amsavardani S.

doi:10.4103/0973-029x.33962

Cited by 11 publications

(8 citation statements)

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“…Thyroid malignancy represents 2% of facial skeleton metastasis [20] and 4.2–6.1% of all jaw metastases [7, 15, 21] 41% of facial skeleton metastasis from thyroid cancer occurs in the mandible; 59% of these metastases are well-differentiated thyroid cancer. There have been 41 reported cases in the literature of thyroid malignancy with metastasis to the mandible of which 21 reported cases were FTC [4, 9–12, 22–47]. There have been 6 reported cases of metastasis to the maxilla; 2 were FTC [22, 48–52].…”

Section: Discussionmentioning

confidence: 99%

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

et al. 2017

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BackgroundFollicular thyroid carcinoma (FTC) metastasis to the facial skeleton is exceedingly rare. A case of FTC metastasizing to the mandible is presented and a systematic review of the literature describing thyroid metastasis to the facial skeleton is performed.Case presentationA 73-year-old female presented with metastatic FTC to the mandible and underwent total thyroidectomy, segmental mandibulectomy, bone impacted fibular free flap reconstruction, and adjuvant radioactive iodine treatment. The PubMed database was searched for literature describing thyroid cancer with facial skeleton metastasis using the key words “thyroid,” “cancer,” “carcinoma,” “metastasis,” and “malignancy” with “oral cavity,” “maxilla,” “mandible,” “sinus,” “paranasal,” and “orbit.” Reports that only involved the soft tissues were excluded. Systematic review revealed 59 cases of well-differentiated thyroid cancer with facial skeleton metastasis: 35 mandibular metastases (21 = FTC), 6 maxilla metastases (2 = FTC), 9 orbital metastases (4 = FTC), and 11 paranasal sinus metastases (7 = FTC). Treatment included surgery, RAI, external beam radiotherapy (XRT), or a combination of these modalities. The one, two, and five-year survival rates were 100%, 79%, and 16%, respectively.ConclusionFacial skeleton metastasis of FTC is a rare clinical challenge. Optimal treatment appears to include total thyroidectomy and resection of involved structures with or without adjuvant treatment.

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Section: Discussionmentioning

confidence: 99%

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

et al. 2017

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“…This case report has demonstrated the initial difficulty in diagnosing a metastatic jaw lesion. Firstly because its presentation may mimic odontogenic infections or even benign tumours clinically (6), and secondly it may be the first manifestation of an undiagnosed malignancy (6)(7)(8). Our patient's initial presentation with toothache and swelling resulted in his initial management in a peripheral hospital by tooth extraction.…”

Section: Discussionmentioning

confidence: 91%

“…In about 30% of cases, the oral lesion provides the first indication of the presence of a previously undiscovered primary cancer (6)(7)(8). The purpose of this report is therefore to highlight the occurrence of this rare condition and also emphasize the need to consider metastatic neoplasm in the differential diagnosis of jaw lesions.…”

Section: Introductionmentioning

confidence: 95%

“…Although prostate cancer has a propensity to metastasize to bone (4,5), the sites of predilection are usually the vertebrae, ribs, long bones and the skull. Metastasis to the jaw is uncommon (6). Indeed among metastatic tumours of the jaws which are a rarity, only about 9% originate from a prostatic primary (7).…”

Section: Introductionmentioning

confidence: 99%

“…Indeed among metastatic tumours of the jaws which are a rarity, only about 9% originate from a prostatic primary (7). The most commonly affected bone is the mandible (60 -80% of cases) with the most frequent location being the molar region (6,8).…”

Section: Introductionmentioning

confidence: 99%

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Prostate cancer metastasis to the mandible: case report

Parkins¹,

Kito²

2010

E Af Med Jrnl

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Prostate cancer is recognised to be the commonest type of malignancy in the male in many parts of the world. Prostate cancer has a propensity to metastasize to bone, however metastasis to the jaw is uncommon and indeed among metastatic tumours of the jaws which are a rarity, only about 9% originate from a prostatic primary. We report a case of histologically proven metastatic prostate cancer to the right mandible which necessitated a hemi-mandibulectomy in order to improve the patient's quality of life.

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Oral metastasis as the first indication of undiscovered malignancy at a distant site: A systematic review of 413 cases

et al. 2022

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This systematic review is the first to provide evidence regarding demographic, clinical, and imaging characteristics, as well as information related to survival, of patients with oral and maxillofacial metastases of occult primary tumors. Case reports, case series, and cross‐sectional studies were included. Ten databases were searched. The risk of bias was assessed using the Joanna Briggs Institute appraisal tools. Overall, 353 articles (413 patients) were included. Statistically significant associations between survival and multiplicity of metastatic foci, and between each of the main primary sites and some features of the oral lesions were observed. Some clinical and imaging characteristics can help dentists in raising diagnostic suspicions and also in relating to plausible primary sites. Early diagnosis of oral and maxillofacial metastases can positively affect the survival rate when they are the only focus of dissemination, conferring an important role on the dentist.

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Metastatic thyroid carcinoma to the mandible

Cited by 11 publications

References 0 publications

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

Prostate cancer metastasis to the mandible: case report

Oral metastasis as the first indication of undiscovered malignancy at a distant site: A systematic review of 413 cases

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