Metastatic trichilemmal carcinoma in a patient with breast cancer

Sofianos, Chrysis; Chauke, Nkhensani Yvonne; Grubnik, Alexandra

doi:10.1136/bcr-2016-217661

Cited by 6 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 87.01% of TLCs (201 of the 231 cases) occurred in the sun-exposed sites (head, neck, arm, and hand), 6.7 times of the non-exposed sites, suggesting the significant role of UV in the pathogenesis of TLC. Ten cases (4.33%) had previous carcinoma: four cases with breast cancer (including Case 2) ( 18 – 20 ), five cases with BCC (two of whom also had SCC) ( 13 ,) ( 21 – 24 ), and one case with both SCC and Bowen’s disease ( 25 ). There were four and six cases in men and women, respectively (c 2 = 0.228, P = 0.633).…”

Section: Resultsmentioning

confidence: 99%

Systematic analysis and case series of the diagnosis and management of trichilemmal carcinoma

Sun

Zhang²,

Xiao³

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

BackgroundTrichilemmal carcinoma (TLC) is a rare malignant cutaneous adnexal neoplasm, with no relatively comprehensive research.ObjectiveThe aim of this study is to perform an updated statistical analysis so as to better understand TLC’s epidemiology, clinical features, diagnosis, and treatment.MethodsThe diagnosis and treatment of three TLC cases in our department were summarized. Then, all TLC cases published in the literature were retrieved for a comprehensive analysis, followed by the analysis of global trends and regional distribution, demographic characteristics, clinical features, pathogenesis, histopathological features, and treatment and prognosis of TLC.ResultsOf the 231 cases, the incidence of TLC has shown an upward trend recently, especially in China, in Asia. The susceptible population is men aged 60–80 and women over 80, and the most prone location is head and neck. The phenotype of TLC is not always typical and may be misdiagnosed because of the coexistence of other diseases. There is a linear relationship between the diameter and its duration or thickness. UV, locally present skin lesions, trauma, scarring, organ transplantation, and genetic disorders may trigger the occurrence of TLC. Periodic acid–Schiff staining and CD34, but not Epithelial Membrane Antigen (EMA), were helpful in the diagnosis of TLC. Although effective, surgical excision and Mohs micrographic surgery need further improvement to reduce recurrence of TLC. Carcinoma history is an independent risk factor for TLC recurrence.LimitationsThe limitation of this study is the lack of randomized controlled trial on TLC treatment and recurrence.ConclusionTLC has the possibility of invasive growth and recurrence, especially in patients with longer duration and carcinoma history.

show abstract

Section: Resultsmentioning

confidence: 99%

Systematic analysis and case series of the diagnosis and management of trichilemmal carcinoma

Sun

Zhang²,

Xiao³

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…[11] We found that most cases on the periorbital region were Stage I or II and most tumors received local surgical excision, some received MMS or methylaminolevulinate-photodynamic therapy. [5,[11][12][13][14][15][16][17][18] There are no published guidelines on the follow-up after treatment of patients with TLC.…”

Section: Discussionmentioning

confidence: 99%

Recurrent trichilemmal carcinoma of the periorbital region treated with IMRT radiotherapy: A case report and a review of literature

Gao

Luo

et al. 2023

Medicine

View full text Add to dashboard Cite

Rationale: Trichilemmal carcinoma (TLC) is a rare malignant cutaneous adnexal tumor usually accept surgery. This report describes an elderly patient with recurrence TLC of the periorbital region after surgery who was subsequently treated with IMRT radiotherapy. After 2-years follow-up visit, there was no progress or metastasis.Introduction: TLC is a rare malignant cutaneous adnexal tumor. It usually occurs on sun-exposed areas in elderly people but rarely occurs in the periorbital region. Most cases accept surgery or micrographic Mohs surgery. Recurrence or metastasis of this neoplasm was seldom reported in the medical literature after enough tumor-free margin surgery. And radiotherapy was seldom reported in the treatment for patients of TLC.Patient concerns: Here we report an elderly patient with recurrence TLC of the periorbital region after surgery who was subsequently treated with radiotherapy with a total dose of 66 Gy. Two years later, the patient was admitted head, neck, chest, abdomen CT scan, and no progress or metastasis was detected after 2-years follow-up.Diagnosis: Trichilemmal carcinoma of the periorbital region.Interventions: We describe the clinical characteristics, pathological features, and choice of examination methods of a patient with TLC in the periorbital region. And we use the radical radiotherapy to treat this case.Outcomes: There are no progress or metastasis after 2-years follow-up. Conclusion:Radiotherapy is a good option for patients with TLC if the patient refuses surgery or fails to achieve a satisfactory tumor-free margin or relapses after surgery.

show abstract

“… 13 In addition, metastatic TC was also reported in a patient with breast cancer. 14 Recently, Ha et al found TP53 mutations in TC patients who had an aggressive clinical course, so genetic alterations identified may further suggest the potential treatment options for TC. 15 Regular follow-up for early detection of recurrence and metastasis is needed.…”

Section: Discussionmentioning

confidence: 99%