Metastatic tumors to the breast: mammographic and ultrasonographic findings.

Lee, Seung Hee; Park, Jeong Mi; Kook, Shin Ho; Han, Boo‐Kyung; Moon, Woo Kyung

doi:10.7863/jum.2000.19.4.257

Cited by 82 publications

(110 citation statements)

References 18 publications

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“…4). (4,5,(9)(10)(11)(12)(19)(20)(21)(22)(23)(24)(25)(26)(27). Twelve of these cases were classified as adenocarcinomas (5,9,12,19,(21)(22)(23)25).…”

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

“…Additionally, 53 cases of breast metastasis from lung tumors were presented; however, no detailed histological classification was provided (7,18,(28)(29)(30). The majority of breast metastases present as palpable, rapidly growing, well-circumscribed and painless breast masses with predilection to the upper outer quadrant (2,7,17,21,22). Unlike primary tumors, the vast majority of metastases do not demonstrate retraction of the skin or nipple, despite their superficial location (5,22).…”

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

“…Additionally, metastatic malignancies are often sharply circumscribed from the surrounding breast tissue. Furthermore, elastosis is common in primary tumors but rare in extra mammary malignancies (2,4,5,12,19,21). Occasionally, metastases to the breast demonstrate features that lead pathologists to the correct diagnosis, such as the presence of pigmentation and intranuclear inclusions in malignant melanomas.…”

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

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Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

et al. 2012

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Abstract. Breast metastasis from extra-mammary malignancy is rare. An incidence of 0.4-1.3% has been reported in the literature. The primary malignancies most commonly metastasizing to the breast are leukemia, lymphoma and malignant melanoma. We present a case of metastasis to the breast from a pulmonary adenocarcinoma, diagnosed concomitantly with the primary tumor. A 43-year-old female presented with dyspnea and a dry cough of 3 weeks' duration. A subsequent chest radiograph revealed a massive pleural effusion. Additionally, on physical examination, a poorly defined mass was noted in the upper outer quadrant of the right breast. The patient underwent bronchoscopy, simple right mastectomy and medical thoracoscopy. Following cytology, histology and immunohistochemistry, primary lung adenocarcinoma with metastasis to the breast and parietal pleura was diagnosed. Histologically, both the primary and metastatic anatomic sites demonstrated a micropapillary component, which has recently been recognized as an important prognostic factor. Although the patient received chemotherapy, she succumbed to her condition within 8 months. Accurate differentiation of metastasis from primary carcinoma is very important as the treatment and prognosis of the two differ significantly. IntroductionThe National Cancer Institute of the USA estimates that, based on current rates, 12.7% of females born today will be diagnosed with breast cancer in their lifetime (1). Although primary breast cancer is the most common malignancy of adult females, metastatic involvement of the breast is rare, with a reported frequency of 0.4-1.3% in clinical series (2-5). Despite its rarity, metastatic breast disease is an significant diagnostic clinical problem, as its treatment differs greatly from that of primary breast cancer. In 1907, Sitzentfrey was the first to publish a case of ovarian carcinoma metastatic to the breast (6). To date, a wide variety of malignancies have now been reported to metastasize to the breast and according to the literature, the most common primary tumors are melanomas and haematological malignancies (5-7). The lung is the most common cancer site in terms of incidence and mortality; however, there have only been a few published cases of pulmonary carcinomas metastasizing to the breast (8-12). Carcinomas with micropapillary components have been reported at several anatomical sites, including the breast, urinary bladder, ovary and major salivary glands (13). Micropapillary components are being increasingly recognized as prognostic predictors in lung adenocarcinomas and according to many studies, this may be a manifestation of aggressive behaviour (14,15). We report the case of a patient with breast metastasis from a pulmonary adenocarcinoma characterized by a micropapillary pattern and diagnosed in conjunction with the primary tumor. Written informed consent was obtained from the patient for publication of this case report and accompanying images. Case reportA 43-year-old, non-smoking housewife presented to the Emergency Departme...

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“…4). (4,5,(9)(10)(11)(12)(19)(20)(21)(22)(23)(24)(25)(26)(27). Twelve of these cases were classified as adenocarcinomas (5,9,12,19,(21)(22)(23)25).…”

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

Section: Histopathological and Immunohistochemical Findingsmentioning

confidence: 99%

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Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

et al. 2012

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“…In general, they do not cause cutaneous nor papillary retraction and tend to be more frequently multiple or bilateral in relation to primary breast neoplasms. The radiographic appearance is of one or more round and well-defined nodules, without microcalcifications in the subcutaneous tissue -except for rare exception, as in cases of ovarian cancer 1,3,6,7 . Mastitis usually occurs among young women and breastfed infants, but may also affect immunosuppressed women.…”

Section: Discussionmentioning

confidence: 99%

Unilateral breast edema due to subclavian vein compression

Avelino¹,

Zanella²,

Bitencourt³

et al. 2017

Rev. Bras. Mastol. (Impr.)

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148Avelino EBP, ZanellaD, Bitencourt AGV, Marques EF O edema mamário unilateral pode ter diferentes causas, que variam desde doenças malignas até benignas. O conhecimento das principais etiologias, associado ao exame clínico detalhado e aos achados radiológicos, é importante para que se estabeleça o diagnóstico correto, e para que se determine o manejo adequado do paciente. Neste artigo, será relatado o caso de uma paciente com câncer de pulmão que desenvolveu edema mamário unilateral; também serão discutidos os principais diagnósticos diferenciais. PALAVRAS-CHAVE:Neoplasias pulmonares; veia subclávia; ultrassonografia mamária; mamografia; neoplasias da mama. RESUMO ABSTRACTUnilateral breast edema may have different causes that vary from malignant to benign diseases. The knowledge of the main etiologies, associated to a detailed clinical examination and to radiological findings, is important in order to establish the correct diagnosis and determine the appropriate management of the patient. This article will report the case of a patient with lung cancer who developed unilateral breast edema; the main differential diagnoses will also be discussed.

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“…Melanomas, lymphomas, leukemias, and sarcomas are the most common malignancies causing breast metastases. Infrequently, carcinomas of the lung, stomach, ovary, liver, tonsil, pleura, pancreas, cervix, perineum, endometrium, bladder, carcinoid tumors, and renal cell carcinomas can cause metastatic breast disease [3][4][5][6]. Bilateral breast metastases are very rare and are reported in few cases of ovarian carcinoma [6].…”

mentioning

confidence: 99%

Primary Rectal Adenocarcinoma Metastasizing to Bilateral Breasts – a Rare Case Demonstrated by 18 F-FDG PET/CT

Soundararajan

Arora

Das

et al. 2015

Nucl Med Mol Imaging

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A 22-year-old female presented with multiple painless bilateral breast masses for the past 2 months. On further questioning, she had hematochezia and constipation for three months. On digital rectal examination, thickening of rectal mucosa at 5 cm from the anal verge was found. On physical examination, multiple firm, non-tender, nodular lesions were found in bilateral breasts. Contrast-enhanced computed tomography (CECT) sagittal, coronal and axial images of the abdomen showed mass-like circumferential wall thickening in the rectum extending to the recto-sigmoid junction, which was suggestive of a primary malignant lesion (Fig. 1a-d, arrows). Sigmoidoscopy showed circumferential growth involving the rectum up to the rectosigmoid junction. Histopathology from the rectal lesion revealed signet ring cell adenocarcinoma. Mammography was performed and the differential diagnoses were primary breast malignancy, bilateral fibroadenoma and metastatic breast disease. 18 F-FDG PET/CT was done to determine the extent of the disease. Maximum intensity projection images of FDG PET showed linear diffuse increased FDG uptake involving the rectal region (Fig. 2a, arrow head), multiple areas of increased FDG uptake in the bilateral breast region (Fig. 2a, arrows), and patchy focal areas of increased FDG uptake in multiple dorso-lumbar vertebrae, multiple bilateral ribs, bilateral scapulae, the humerus, the pelvic bones, the left femur proximal shaft and in the left paravertebral region. Sagittal sections of fused 18 F-FDG PET/CT images (Fig. 2b) show subtle lytic changes with increased FDG uptake in multiple cervico-dorsal and lumbar vertebrae and the sternum, and Fig. 2c (arrow) shows circumferential thickening of the rectum with increased FDG uptake. Axial sections of fused PET/CT images (Figs. 2d, e) show multiple FDG-avid soft tissue density lesions involving bilateral breast parenchyma. 18 F-FDG PET/CT findings were suggestive of an active primary malignant disease involving the rectum with a metastatic disease involving extensive skeletal sites, bilateral breasts and retroperitoneal lymph nodes.A biopsy taken of bilateral breast masses showed a malignant tumor comprising of neoplastic cells in sheets with intracellular mucin and eccentrically pushed pleomorphic nuclei (signet ring cells) along with pools of extracellular mucin in hematoxylin and eosin-stained sections (Figs. 3a, b; 40X) which was consistent with metastatic signet ring cell adenocarcinoma to both breasts.Metastatic breast disease from extramammary primaries is uncommon and it constitutes 0.5 -6 % of all breast malignancies [1,2]. Melanomas, lymphomas, leukemias, and sarcomas are the most common malignancies causing breast metastases. Infrequently, carcinomas of the lung, stomach, ovary, liver, tonsil, pleura, pancreas, cervix, perineum, endometrium, bladder, carcinoid tumors, and renal cell carcinomas can cause metastatic breast disease [3][4][5][6]. Bilateral breast metastases are very rare and are reported in few cases of ovarian carcinoma [6]. Rectal aden...

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Metastatic tumors to the breast: mammographic and ultrasonographic findings.

Cited by 82 publications

References 18 publications

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

Breast metastasis from a pulmonary adenocarcinoma: Case report and review of the literature

Unilateral breast edema due to subclavian vein compression

Primary Rectal Adenocarcinoma Metastasizing to Bilateral Breasts – a Rare Case Demonstrated by 18 F-FDG PET/CT

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