Metastatic Versus Primary Oncocytic Papillary Adenocarcinoma of the Endometrium: A Report of a Case and Review of the Literature

Abstract

We report a case of an oncocytic papillary adenocarcinoma of the endometrium in an 89-year-old female with vaginal bleeding. Imaging studies revealed lesions in the uterus, kidneys, pancreas, gluteus, and an enlarged portacaval lymph node. Diagnostic workup included an endometrial biopsy which showed malignant, oncocytic cells in a predominantly papillary pattern. These cells stained positive for epithelial markers (pan-cytokeratin, CK7, epithelial membrane antigen) and weakly for estrogen receptor. The cells were negative for cytokeratin 903, CAM 5.2, progesterone receptor, CD10, RCC Marker, CA-125, c-kit, and vimentin. Consultation with experts in Gynecologic and Genitourinary pathology returned a diagnosis of "adenocarcinoma compatible with metastatic renal cell carcinoma"--an intriguing possibility worthy of further exploration. To our knowledge, there are no reports in the literature of metastatic oncocytic papillary renal cell carcinoma to the endometrium. The clinical and pathologic features of oncocytic papillary endometrial lesions, including primary and metastatic processes, are reviewed.

Case report: Renal cell carcinoma with metastasis to the myometrium

“…Common sites of metastasis include the lungs, liver, adrenals, skin and bone . The involvement of female reproductive organs is rare, and the involvement of the uterus is extremely rare; to our knowledge only 10 cases of RCC with metastasis to the uterine endometrium/cervix have been published in the current literature . Our case represents the first case of RCC with metastasis to the myometrium.…”

A rare case of renal and uterine clear cell carcinoma: Which is the primary tumour?

“…Common sites of metastasis in patients with renal cell carcinoma in order of decreasing frequency are lungs, lymph nodes, liver, bone, adrenal gland, soft tissue, and brain [1]. However, renal cell carcinoma metastasis to the uterusis still surprisingly rare and thus far less than five cases have been reported [2][3][4][5]. We report a case of renal cell carcinoma with uterine metastasis and further describe the method of differentiating primary renal cell carcinoma with uterine metastasis, from primary uterine carcinoma with uterine metastasis.…”