2022
DOI: 10.1016/j.ecoenv.2022.113461
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Metformin alleviates nickel-refining fumes-induced aerobic glycolysis via AMPK/GOLPH3 pathway in vitro and in vivo

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Cited by 4 publications
(3 citation statements)
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“…Therefore, the traceable effect of metformin in inhibiting nickel‐induced ROS is supported. In addition to our previous evidence, metformin also counters nickel‐refined smoke‐induced aerobic glycolysis and cell apoptosis through the ROS/AMPK/GOLPH3 pathway 40,41 …”
Section: Discussionsupporting
confidence: 56%
See 1 more Smart Citation
“…Therefore, the traceable effect of metformin in inhibiting nickel‐induced ROS is supported. In addition to our previous evidence, metformin also counters nickel‐refined smoke‐induced aerobic glycolysis and cell apoptosis through the ROS/AMPK/GOLPH3 pathway 40,41 …”
Section: Discussionsupporting
confidence: 56%
“…In addition to our previous evidence, metformin also counters nickel-refined smoke-induced aerobic glycolysis and cell apoptosis through the ROS/AMPK/GOLPH3 pathway. 40,41 In addition, evidence has demonstrated that metformin can substantially modulate the processes involved in histone modifications, DNA methylation and miRNAs via the regulation of epigenetic-related gene expression. In our past studies, metformin, in addition to preventing autophagy, can also reduce the expression of oncogenes and reduce the ability to metastasis.…”
Section: Discussionmentioning
confidence: 99%
“…Under conditions of metabolic stress, such as hypoxia and ischemia, AMPK is activated to increase ATP production and reduce ATP consumption to maintain cellular energy homeostasis (Burkewitz et al, 2014;Hardie, 2015). Zhang et al (2022) showed that AMPK antagonizes nickel-refining fume-induced aerobic glycolysis. Similarly, Tang et al (2021) found that enhanced glycolysis in lung fibroblasts induced by LPS can be prevented by regulating the AMPK pathway.…”
Section: Frontiers In Physiologymentioning
confidence: 99%