Metformin effect on driving cell survival pathway through inhibition of UVB-induced ROS formation in human keratinocytes

Ribeiro, Fabianne Martins; Ratti, Bianca Altrão; Rando, Fabiana dos Santos; Fernandez, Maria Aparecida; Ueda-Nakamura, Tânia; Silva, Sueli de Oliveira

doi:10.1016/j.mad.2020.111387

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…These results indicate that time and temperature play important roles in the changes in phenolic composition during heat treatment [41]. Isoliquiritigenin inhibits ROS production and the NF-κB pathway [5]. Increased isoliquiritigenin in HL extracts may have increased antioxidant activity and inhibited ROS generation and activation of NF-κB p65 in UVB-exposed HDFs [15,42,43], thereby suppressing the expression of COX-2, iNOS, and cytokines.…”

Section: Discussionmentioning

confidence: 90%

“…κB pathway [5]. Increased isoliquiritigenin in HL extracts may have increased antioxidant activity and inhibited ROS generation and activation of NF-κB p65 in UVB-exposed HDFs [15,42,43], thereby suppressing the expression of COX-2, iNOS, and cytokines.…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to UVB leads to DNA damage, pigmentation, and inflammatory diseases, and excessive exposure can lead to skin cancer [3,4]. Exposure to UVB also indirectly induces oxidative DNA damage through the generation of reactive oxygen species (ROS) [5]. Inflammation-related pathways in the skin, such as the nuclear factor kappa B (NF-κB) pathway, are activated by ROS [6].…”

Section: Introductionmentioning

confidence: 99%

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Heat Treatment Improves UV Photoprotective Effects of Licorice in Human Dermal Fibroblasts

Park

Ji²,

Seo

et al. 2021

Processes

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External stimulation of the skin by ultraviolet B (UVB) radiation induces oxidative stress or inflammation, causing skin aging and skin cancer. Glycyrrhiza uralensis (licorice) has been used as a medicinal plant for its antioxidant, anti-inflammatory, antiviral, antimicrobial, anticarcinogenic, and hepatoprotective properties. The present study analyzed the effects of thermal processing on the bioactivities of licorice. Heat-treated licorice (HL) extracts had better antioxidant and anti-inflammatory activities than nontreated licorice (NL) extract. HL extracts also had higher total phenol contents than NL extract. In particular, contents of isoliquiritigenin, an antioxidant and anti-inflammatory substance of licorice, increased in proportion to the skin-protection effects of HL extracts. Heat treatment increased the contents of phenolic compounds such as isoliquiritigenin in licorice extract, which improved the UV photoprotective effect of licorice in human dermal fibroblasts.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heat Treatment Improves UV Photoprotective Effects of Licorice in Human Dermal Fibroblasts

Park

Ji²,

Seo

et al. 2021

Processes

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“…Different wavelengths of UV can induce the skin to produce different types of ROS ( 30 ). Among them, UVB mainly stimulates the production of O 2- through the activation of NADPH oxidase and the respiratory chain reaction ( 36 ), while UVA generates H 2 O 2 through the photosensitization reaction with internal chromophores such as riboflavin and porphyrin ( 37 ). Therefore, scavenging intracellular ROS can alleviate skin damage caused by UV and is also a potential target for preventing photoaging.…”

Section: Discussionmentioning

confidence: 99%

Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Jiang

Zhou

2022

Exp Ther Med

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“…Metformin decreases ROS production by directly acting on mitochondrial nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and class 1 respiratory chain enzymes and can be considered an antioxidant agent [ 58 ]. Metformin interferes with mitochondria and reduces ATP production, leading to the activation of AMPK [ 59 ], which has been shown to reduce ROS levels, increase the expression of the antioxidant thioredoxin and induce the antioxidant status of vascular endothelial cells [ 60 ].…”

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease

Cheng¹,

Li²,

Du³

et al. 2022

Aging and disease

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Aging is a major global challenge, and there is growing demand for new strategies to address the burden of aging. The intensive search for antiaging agents has led to the discovery of a variety of drugs that promote the extension of healthspan and/or life. Metformin is a safe, effective, and globally affordable antihyperglycemic agent that has gained much attention in recent years as a potential antiaging treatment. Metformin has been shown to significantly delay the onset of age-related diseases and increase lifespan in several model organisms. In this paper, we reviewed aging hallmarks and the role of metformin in countering these hallmarks. We examined the beneficial effects of metformin on several age-related diseases and the feasibility of metformin as an agent to extend lifespan and healthspan. Finally, we discussed new research directions to better understand the translational potential of metformin in humans.

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Metformin effect on driving cell survival pathway through inhibition of UVB-induced ROS formation in human keratinocytes

Cited by 6 publications

References 35 publications

Heat Treatment Improves UV Photoprotective Effects of Licorice in Human Dermal Fibroblasts

Heat Treatment Improves UV Photoprotective Effects of Licorice in Human Dermal Fibroblasts

Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease

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