Metformin Improves Glucose, Lipid Metabolism, and Reduces Blood Pressure in Hypertensive, Obese Women

Giugliano, Dario; Rosa, Nicoletta De; Maro, G. Di; Marfella, R; Acampora, R; Buoninconti, R; D'Onofrio, F

doi:10.2337/diacare.16.10.1387

Cited by 196 publications

(115 citation statements)

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“…Thus, we were neither able to support nor rule out the previously suggested beneficial effect of metformin on BP in insulin-resistant hypertensives [6] or obese female subjects [7].…”

Section: Discussioncontrasting

confidence: 95%

“…An effect related to hyperinsulinaemia is supported by a study of spontaneously hypertensive rats [13]. The present study population had higher diastolic and systolic BP at baseline compared to the study of Giugliano et al [7]. We found only a minor (5 mmHg) but significant decline in diastolic office blood pressure within the group of metformin-treated patients.…”

Section: Discussionsupporting

confidence: 75%

“…Studies of the effect of metformin on blood pressure in NIDDM patients are not conclusive [5]. In most studies of the effect in nondiabetic subjects [6][7][8][9], both plasma insulin and blood pressure (BP) are reduced. Especially in the pilot study of Landin et al [6], a large reduction of BP was observed during metformin treatment.…”

Section: Introductionmentioning

confidence: 99%

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The effect of metformin on blood pressure and metabolism in nondiabetic hypertensive patients

Snorgaard

Køber

Carlsen³

1997

Journal of Internal Medicine

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Results. The possible effect of metformin treatment and dosage was tested with a two-factor analysis of variance. Treatment induced a significant decline in diastolic oBP, P Ͻ 0.05. This decline was, however, not significantly different comparing metformin and placebo. Systolic oBP, diastolic aBP, and systolic aBP showed no significant change by treatment. The decline in diastolic oBP was 5 mmHg in the pooled group of metformin-treated patients, P Ͻ 0.005. Different gender and the presence of obesity had no impact on the decline in diastolic oBP within this group. Changes in fasting C-peptide and fasting insulin during treatment were unrelated to blood pressure changes. High fasting insulin (Ͼ 60 pmol L Ϫ1 ) or high fasting C-peptide (Ͼ 1000 pmol L Ϫ1 ) at baseline did not favour an effect of metformin on diastolic oBP. Glucose metabolism and lipoproteins were unchanged in all groups. Conclusions. Although metformin treatment induced a decline in diastolic office blood pressure in nondiabetic hypertensives, the decline was not different from that during placebo treatment. Metformin had no significant effect on ambulatory blood pressure. Thus, metformin has, if any, only a minor clinically insignificant effect on blood pressure in nondiabetic hypertensives. The study does not support the hypothesis that circulating insulin is a major regulator of blood pressure in hypertension.

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“…Thus, we were neither able to support nor rule out the previously suggested beneficial effect of metformin on BP in insulin-resistant hypertensives [6] or obese female subjects [7].…”

Section: Discussioncontrasting

confidence: 95%

Section: Discussionsupporting

confidence: 75%

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The effect of metformin on blood pressure and metabolism in nondiabetic hypertensive patients

Snorgaard

Køber

Carlsen³

1997

Journal of Internal Medicine

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“…Why? One could speculate it reflects the known CV benefits of metformin over sulfonylureas, less weight gain and lowered triglyceride levels (8,9), and the resulting effects on potential CV pathogenic mechanisms such as plasminogen activator inhibitor-1 (10). To be valid, it needs to be shown that CV-related mortality was in fact low-ered.…”

mentioning

confidence: 99%

Is Metformin Cardioprotective?

Sasali

Leahy

2003

Diabetes Care

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“…This also seems to contradict the hypothesis of a direct relationship between insulin sensitivity and blood pressure level. [18][19][20][21] We have earlier demonstrated that in spite of an impaired insulin-stimulated glucose uptake the insulin-induced tubular sodium reabsorption is retained in relatives. 12 The suppression of plasma aldosterone observed in controls during the clamp was blunted in relatives, which could suggest a tendency to sodium retention in these subjects.…”

Section: Discussionmentioning

confidence: 99%

Insulin sensitivity with respect to glucose metabolism in hypertension-prone men did not predict the blood pressure increase in 5 years

2001

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Objectives: To evaluate peripheral insulin stimulated glucose uptake as a predictor for increase in blood pressure in hypertension-prone men. Design: A follow-up study 5 years after a primary investigation that included an euglycaemic hyperinsulinaemic clamp to evaluate insulin sensitivity. Subjects: Thirty-two men with a family history of hypertension (relatives) and 22 men with no hypertension in the family (controls). All were normotensive and had a normal glucose tolerance. Main outcome measures: Change in blood pressure over 5 years and its relation to the values obtained in the basal investigation. Results: Systolic and diastolic blood pressure increased in both groups during the 5 years, but dia-

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Metformin Improves Glucose, Lipid Metabolism, and Reduces Blood Pressure in Hypertensive, Obese Women

Abstract: These findings suggest that metformin treatment in obese, nondiabetic, hypertensive women produces a more favorable cardiovascular risk profile.

Cited by 196 publications

References 0 publications

The effect of metformin on blood pressure and metabolism in nondiabetic hypertensive patients

The effect of metformin on blood pressure and metabolism in nondiabetic hypertensive patients

Is Metformin Cardioprotective?

Insulin sensitivity with respect to glucose metabolism in hypertension-prone men did not predict the blood pressure increase in 5 years

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