Methamphetamine and the hypothalamic-pituitary-adrenal axis

Zuloaga, Damian G.; Jacobskind, Jason S.; Raber, Jacob

doi:10.3389/fnins.2015.00178

Cited by 39 publications

(28 citation statements)

References 79 publications

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“…38 Furthermore, hyperactivity of the hypothalamic-pituitary-adrenal axis has been proposed as a possible mechanism of induction of depression in methamphetamine users. 39 The current study also suggested that reuse of methamphetamine in the follow-up could significantly predict all of the assessed clinical symptoms including manic, depressive, and positive and negative psychotic symptoms. This prediction is much stronger for positive psychotic and manic symptoms but not so strong for depressive and negative psychotic symptoms, in which their respective baseline values are better predictors.…”

Section: Discussionsupporting

confidence: 60%

Clinical Course of Methamphetamine-Induced Psychotic Disorder in a 3-Month Follow-Up

Javadian

Shabani

Shariat³

2016

Prim. Care Companion CNS Disord.

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Various symptom categories do not always change in the same direction during the course of the disorder, especially depressive symptoms that do not improve with abstinence but aggravate with frequency of methamphetamine use. Negative symptoms at baseline also seem to have a possible role in prediction of methamphetamine reuse in patients with MIPD. Physicians should be advised to independently address all of the symptom categories of their patients with MIPD at each follow-up visit.

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Section: Discussionsupporting

confidence: 60%

Clinical Course of Methamphetamine-Induced Psychotic Disorder in a 3-Month Follow-Up

Javadian

Shabani

Shariat³

2016

Prim. Care Companion CNS Disord.

View full text Add to dashboard Cite

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“…Studies in children following prenatal MA exposure in the context of alterations in HPA axis function, find that MA exposure is associated with newborn neurobehavioral patterns of increased stress and cortisol (Smith et al 2008; LaGasse et al 2011; Kirlic et al 2013; Twomey et al 2013; Zuloaga et al 2015). In neonatal rats, MA administration increases CORT release (Schaefer et al 2006, 2008, 2010; Williams et al 2006; Grace et al 2010a, b).…”

Section: Introductionmentioning

confidence: 99%

Effects of Neonatal Methamphetamine and Stress on Brain Monoamines and Corticosterone in Preweanling Rats

2016

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Neonatal exposure to methamphetamine (MA) and developmental chronic stress significantly alter neurodevelopmental profiles that show a variety of long-term physiological and behavioral effects. In the current experiment, Sprague-Dawley rats were exposed to one of two housing conditions along with MA. Rats were given 0 (saline), 5, or 7.5 mg/kg MA, four times per day from postnatal day (P)11 to 15 or P11 to 20. Half of the litters were reared in cages with standard bedding and half with no bedding. Separate litters were assessed at P15 or P20 for organ weights (adrenals, spleen, thymus); corticosterone; and monoamine assessments (dopamine, serotonin, norepinephrine) and their metabolites within the neostriatum, hippocampus, and prefrontal cortex. Findings show neonatal MA altered mono-amines, corticosterone, and organ characteristics alone, and as a function of developmental age and stress compared with controls. These alterations may in part be responsible for MA and early life stress-induced long-term learning and memory deficits.

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“…As a result, this repeated exposure to high levels of glucocorticoids may produce harmful effects on the brain (e.g., cell death, decreased neurogenesis) similar to those induced by chronic stress (Uno et al 1989; Pham et al 2003). These chronic elevations in glucocorticoids may also be linked to behavioral modifications reported following chronic MA exposure, including altered anxiety- and depression-related behaviors (Nawata et al 2012; Jang et al 2013; London et al 2004; Zuloaga et al 2015b). …”

Section: Discussionmentioning

confidence: 99%

Immediate and lasting effects of chronic daily methamphetamine exposure on activation of cells in hypothalamic-pituitary-adrenal axis-associated brain regions

et al. 2015

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Rationale Chronic methamphetamine (MA) abuse leads to dependence and symptoms of withdrawal after use has ceased. Negative mood states associated with withdrawal, as well as drug reinstatement, have been linked to drug-induced disruption of the hypothalamic-pituitary-adrenal (HPA) axis. However, effects of chronic MA exposure or acute MA exposure following withdrawal on neural activation patterns within brain regions that regulate the HPA axis are unknown. Objectives In this study, neural activation patterns were assessed by quantification of c-Fos protein in mice exposed to different regimens of MA administration. Methods (Experiment 1) Adult male mice were treated with MA (5 mg/kg) or saline once or once daily for 10 days. (Experiment 2) Mice were treated with MA or saline once daily for 10 days and following a 10-day withdrawal period were re-administered a final dose of MA or saline. c-Fos was quantified in brains after the final injection. Results (Experiment 1) Compared to exposure to a single dose of MA (5 mg/kg), chronic MA exposure decreased the number of c-Fos expressing cells in the paraventricular hypothalamus, dorsomedial hypothalamus, central amygdala, basolateral amygdala, bed nucleus of the stria terminalis (BNST), and CA3 hippocampal region. (Experiment 2) Compared to mice receiving their first dose of MA, mice chronically treated with MA, withdrawn, and re-administered MA, showed decreased c-Fos expressing cells within the central and basolateral amygdala, BNST, and CA3. Conclusions HPA axis-associated amygdala, extended amygdala, and hippocampal regions endure lasting effects following chronic MA exposure and therefore may be linked to stress-related withdrawal symptoms.

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Methamphetamine and the hypothalamic-pituitary-adrenal axis

Cited by 39 publications

References 79 publications

Clinical Course of Methamphetamine-Induced Psychotic Disorder in a 3-Month Follow-Up

Clinical Course of Methamphetamine-Induced Psychotic Disorder in a 3-Month Follow-Up

Effects of Neonatal Methamphetamine and Stress on Brain Monoamines and Corticosterone in Preweanling Rats

Immediate and lasting effects of chronic daily methamphetamine exposure on activation of cells in hypothalamic-pituitary-adrenal axis-associated brain regions

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