2018
DOI: 10.1097/mcp.0000000000000513
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Methamphetamine and the risk of pulmonary arterial hypertension

Abstract: PAH patients undergoing diagnostic evaluation should be screened for a history of current or past methamphetamine use. Pharmacovigilance should be implemented to monitor patients being treated with methamphetamine for neuropsychiatric disorders (e.g., attention-deficit hyperactivity disorder). More studies will be needed to identify which susceptibility factors increase risk of PAH in methamphetamine users.

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Cited by 32 publications
(16 citation statements)
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“…7. COVID-19 itself has potential to increase overdose risk among people with SUD with chronic lung disease, previously identified as a risk factor for overdose mortality [16], and methamphetamine use may place people at increased risk of pulmonary hypertension [17], a risk factor for COVID-19 complications.…”
Section: Opioid Agonist Treatment (Oat) Should Bementioning
confidence: 99%
“…7. COVID-19 itself has potential to increase overdose risk among people with SUD with chronic lung disease, previously identified as a risk factor for overdose mortality [16], and methamphetamine use may place people at increased risk of pulmonary hypertension [17], a risk factor for COVID-19 complications.…”
Section: Opioid Agonist Treatment (Oat) Should Bementioning
confidence: 99%
“…Those suffering from substance abuse and addiction represent a particularly vulnerable population during the COVID-19 crisis. Opiate dependence is known to be a risk factor for poor outcome with respiratory disease, whilst chronic methamphetamine use can led to pulmonary hypertension and heart failure, associated with worsened outcomes from COVID-19 [41,[81][82][83]. There is high collinearity between substance abuse and severe psychiatric disease, and those with either condition are more likely to experience homelessness or incarceration, which increases risk of poor COVID-19 outcomes [41].…”
Section: Psychiatry and Behavioural Medicinementioning
confidence: 99%
“…Within the United States, it has been commonly accepted that methamphetamine use varies significantly by region, with higher rates of use in the West and Midwest ( 3 5 ). Potential explanations for this difference range from differences in drug manufacturing and distributing, with more direct drug trafficking through Mexico through the western half of the country, to higher rates of depression, suicide, and concomitant drug use at higher elevations ( 1 , 3 , 4 , 6 ).…”
mentioning
confidence: 99%