Methane to bioproducts: the future of the bioeconomy?

Pieja, Allison J.; Morse, Molly; Cal, Andrew J.

doi:10.1016/j.cbpa.2017.10.024

Cited by 96 publications

(48 citation statements)

References 69 publications

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“…Additionally, it has been demonstrated that plastics can make their way up the food chain, causing similar health threats to humans. This situation has encouraged an intensive research to find and produce biodegradable and non-toxic plastics or biopolymers, such as polyhydroxyalkanoates (PHAs) which could definitively substitute and end the use of pollutant plastics (Löhr et al, 2017;Pieja et al, 2017;Sigler, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…The PHAs are synthesized under nutrient-limited and carbon-excess conditions by different microorganisms (Pieja et al, 2017). The most common feedstock used for production of PHAs are glucose and fructose, but those carbon sources have a high price, due the market price of PHAs is higher (4-20 € KgPHA -1 ) (Koller et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…An innovative feasible alternative to enhance the economic sustainability of the degradation and valorization of CH 4 combined to the concomitant replacement of common plastics is the coproduction of polyhydroxyalkanoates (PHAs) combined with the treatment of methane emissions (Cal et al, 2016;Pieja et al, 2017;Strong et al, 2016) . Indeed, several studies have demonstrated that methanotrophs are a potential source of bioplastics, achieving PHA contents ranging from 20 to 60 % (wt) using methane as feedstock (Cantera et al, 2019;Pieja et al, 2017). Methanotrophs are divided into two different groups according to the pathway for carbon assimilation a) type I (-proteobacteria) use the ribulose monophosphate (RuMP) pathway or b) type II (-proteobacteria) use of the serine pathway.…”

Section: Introductionmentioning

confidence: 99%

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The effect of temperature during culture enrichment on methanotrophic polyhydroxyalkanoate production

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Cantera

Bordel

et al. 2019

International Biodeterioration & Biodegradation

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Climate change and plastic pollution are likely the most relevant environmental problems of the 21 st Century. Thus, one of the most promising solutions to remedy both environmental problems simultaneously is the bioconversion of greenhouse gases, such as methane (CH 4), into bioplastics (PHAs). However, the optimization of this bioconversion platform is still required to turn CH 4 biotransformation into a cost-effective and costcompetitive process. In this context, the research presented here aimed at elucidating the best temperature culture conditions to enhance both PHA accumulation and methane degradation. Six different enrichments were carried out at 25, 30 and 37ºC using different inocula and methane as the only energy and carbon source. CH 4 biodegradation rates, specific growth rates, PHA accumulations and the community structure were characterized. Higher temperatures (30 and 37ºC) increased the PHAs accumulation up to 30% regardless of the inoculum. Moreover, Methylocystis became the dominant genus (~ 30% of the total population) regardless of the temperature and inoculum used. This research demonstrated for the first time the fundamental role of temperature in increasing both the accumulation of PHAs and methane abatement during the enrichment of PHA cell-factories from methane, thus enhancing the cost-effectiveness of the process.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effect of temperature during culture enrichment on methanotrophic polyhydroxyalkanoate production

Pérez

Cantera

Bordel

et al. 2019

International Biodeterioration & Biodegradation

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“…Pieja et al have reviewed a number of studies that explore potential gas‐to‐products technologies using methanotrophic organisms. Methanol, which is the first product of aerobic methane oxidation, presents a similarly suitable feedstock for biotechnological applications.…”

Section: Introductionmentioning

confidence: 99%

Microbial Methylotrophic Metabolism: Recent Metabolic Modeling Efforts and Their Applications In Industrial Biotechnology

Lieven

Sonnenschein

2018

Biotechnology Journal

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Developing methylotrophic bacteria into cell factories that meet the chemical demand of the future could be both economical and environmentally friendly. Methane is not only an abundant, low-cost resource but also a potent greenhouse gas, the capture of which could help to reduce greenhouse gas emissions. Rational strain design workflows rely on the availability of carefully combined knowledge often in the form of genome-scale metabolic models to construct high-producer organisms. In this review, the authors present the most recent genome-scale metabolic models in aerobic methylotrophy and their applications. Further, the authors present models for the study of anaerobic methanotrophy through reverse methanogenesis and suggest organisms that may be of interest for expanding one-carbon industrial biotechnology. Metabolic models of methylotrophs are scarce, yet they are important first steps toward rational strain-design in these organisms.

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“…In for bioplastic production using methane as feedstock (Petersen et al, 2017;Pieja et al, 2017;Ritala et al, 2017). However, there is still a larger field of methanebased bioproducts unexploited, being undoubtedly one of the most profitable of them, the production of ectoines (hydroxyectoine and ectoine) (Cantera et al, 2016a).…”

Section: Introductionmentioning

confidence: 99%

Innovative approaches for enhancing the cost-efficiency of biological methane abatement

Cantera¹

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Para ello se diseñó, implementó y evaluó un biorreactor de columna por burbujeo para el tratamiento de CH 4 que permitiera la producción simultánea de varios bioproductos de alto valor agregado usando un consorcio metanótrofo haloalcalófilo enriquecido, conformado principalmente por los géneros Halomonas, Marinobacter, Methylophaga y Methylomicrobium. Este consorcio fue capaz de acumular en continuo la misma concentración de ectoína que M. alcaliphilum (80 mg ectoína g biomasa-1) y co-producir además hidroxiectoína (13 mg hidroxiectoina g biomasa-1) y exopolisacáridos (hasta 2.6 g EPS g biomasa-1). Desafortunadamente, este consorcio no fue capaza de sintetizar bioplásticos bajo estas condiciones de operación, ya que su síntesis requiere de la limitación de nutrientes lo que conllevaría una diminución de la producción del resto de bioproductos. Este trabajo constituyó el primer estudio de viabilidad de la co-producción de bioproductos comerciales a partir de metano, lo que permitiría mejorar el balance económico de los tratamientos biológicos actuales gracias a la comercialización de los bioproductos obtenidos. Por otro lado, el enriquecimiento de nuevos microorganismos metanótrofos halotolerantes permitió el aislamiento de dos nuevas especies capaces de oxidar metano a alta salinidad: Alishewanella sp. strain RM y Halomonas sp. strain PGE (géneros no identificados hasta el momento como degradadores de metano). Halomonas sp. strain PGE fue capaz de sintetizar ectoína (70-92 mg ectoína g biomasa-1) a mayores concentraciones que los metanótrofos productores de ectoína identificados hasta el momento (entre 37.4 y 70.0 mg ectoína g biomasa-1). Sin embargo, su crecimiento se veía probablemente inhibido por la producción de un metabolito tóxico en el proceso de degradación de metano, lo que obligaba a aumentar la tasa de dilución del medio mineral para mantener la capacidad de degradación de CH 4. Finalmente, se evaluó el efecto del cobre, de la concentración de CH 4 y de la velocidad de transferencia durante el enriquecimiento de microorganisms metanótrofos en sistemas en lote. Los resultados obtenidos demostraron que un incremento en la concentración de cobre de 0.05 a 25 μM aumentaba la q max y K s de las comunidades enriquecidas en un factor de 3. Además, se observó por primera vez que altas concentraciones de cobre promovían el crecimiento de poblaciones más especializadas y menos diversas. Aunque la concentración de CH 4 no tuvo un efecto significativo sobre la estructura microbiana o su cinética de Resumen VI degradación de CH 4 a las dos concentraciones estudiadas (4 y 8%), este estudio constituyó una prueba empírica sólida de la importancia de las condiciones de enriquecimiento en las características de las comunidades metanótrofas, identificándose el cobre como un factor crucial para mantener una alta eficiencia y resiliencia en la degradación de metano. Los resultados de esta tesis constituyen una primera aproximación al tratamiento de gases basado en el concepto de biorrefinería, y abren una nueva puerta al ...

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Methane to bioproducts: the future of the bioeconomy?

Cited by 96 publications

References 69 publications

The effect of temperature during culture enrichment on methanotrophic polyhydroxyalkanoate production

The effect of temperature during culture enrichment on methanotrophic polyhydroxyalkanoate production

Microbial Methylotrophic Metabolism: Recent Metabolic Modeling Efforts and Their Applications In Industrial Biotechnology

Innovative approaches for enhancing the cost-efficiency of biological methane abatement

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