Methanol extract of Ficus platyphylla decreases cerebral ischemia induced injury in mice

Effects of <i>Ficus Platyphylla</i>-Induced Hypothermia on Long-term Functional Recovery after Ischaemic Stroke

“…A higher number of cells and neurons were found in the peri-infarct area in both groups of mice. Fic-induced hypothermia protected the peri-infarct region from synaptophysin reduction and reduced NMDA receptor 2 immunoreactivity [11]. These results suggest that Fic-induced hypothermia had a protective effect on different levels of ischemia-induced brain damage.…”

“…The model 'permanent occlusion of the middle cerebral artery' (MCAO) was used, and the brains were observed 24 h after MCAO. The plant extract induced hypothermia for at least 8 hours after intraperitoneal injection [11]. Administration of Fic 1 h before MCAO significantly reduced infarct volume, with no significant effect on infarct volume immediately after MCAO.…”

“…The identification, collection, and methanol extraction of Ficus platyphylla stem bark and highperformance liquid chromatography analysis of the extract, have been described previously [12,13]. The quote was dissolved in physiological saline and injected intraperitoneally (ip) at a volume of 10 ml/kg body weight (bw) 1 h prior to MCAO or immediately after MCAO in a dose of 50 mg/kg bw [11]. This dose was selected based on its effect on body temperature [11].…”

“…Recently, we investigated the effect of methanol stem bark extract of Ficus platyphylla (Fic) on core body temperature and cerebral ischemia-induced brain damage in mice [11]. The model 'permanent occlusion of the middle cerebral artery' (MCAO) was used, and the brains were observed 24 h after MCAO.…”

Traditional medicinal plants used for treating emerging and re-emerging viral diseases in northern Nigeria

“…Used to treat bronchitis, stomach ache and asthma in Nigeria, as love potion in Ghana and antimalaria, fever in India [173] , [174] , [175] Higher doses were not lethal or toxic in rats [175] Poliomyelitis Ficus platyphylla Delile Used to treat insomnia, psychosis, depression, epilepsy, pain and as an analgesic in Northern Nigeria [176] . Used to treat malaria and tuberculosis in Africa [177] Induced antimalarial activity, behavioral and anticonvulsant effect, sedative effect, decreased cerebral ischemia, antimalarial and anti-inflammatory [177] , [178] , [179] , [180] Intraperitoneal and oral LD 50 were greater than 2000 mg/kg and 5000 mg/kg, respectively [176] Poliomyelitis, smallpox, yellow fever, meningitis, monkey pox Ficus polita Vahl Used to treat infectious diseases, abdominal pain, dyspepsia and diarrhea [181] LD 50 of aqueous stem bark > 5000 mg/kg [182] Poliomyelitis, smallpox, yellow fever, meningitis, monkey pox, COVID-19 Ficus sycomorus L. Used to treat cough, skin infection, liver disease, diarrhea tuberculosis and stomach problem in Oman. Used to treat jaundice, ulcers, inflammation and respiratory and chest disease [ 183 , 184 ] The LD 50 of aqueous root extract was 3.20 ± 0.60 g/kg characterized by liver toxicity [184] Poliomyelitis, meningitis, hepatitis, yellow fever Ficus thonningii Blume Used to treat diarrhea, gonorrhea and diabetes mellitus, bronchitis, urinary tract infection in Angola.…”