Methanol poisoning with necrosis corpus callosum

Keleş, Gönül Tezcan; Örgüç, Şebnem; Toprak, Baris; Özaslan, Sabri; Sakarya, Melek

doi:10.1080/15563650701251794

Cited by 8 publications

(3 citation statements)

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“…Many patients develop Parkinsonism after poisoning by methanol, a finding that is consistent with the lesions in the basal ganglia lesions. In addition to clinical and laboratory findings, the existence of the putamen hemorrhage and insular sub cortex white matter necrosis is associated with a poor clinical outcome in patients with methanol toxicity [ [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] ] ( Table 1 ). Both the retinal and neurological effects of MP may be permanent (see Fig.…”

Section: Discussionmentioning

confidence: 99%

Methanol poisoning as a new world challenge: A review

Nekoukar

Zakariaei

Taghizadeh

et al. 2021

Annals of Medicine &Amp; Surgery

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Background Methanol poisoning (MP) occurs often via ingestion, inhalation, or dermal exposure to formulations containing methanol in base. Clinical manifestations of MP include gastrointestinal symptoms, central nervous system (CNS) suppression, and decompensated metabolic acidosis occurred with blurred vision and early or late blindness. Objective This study reviewed the clinical manifestations, laboratory and radiology findings, and treatment approaches in MP. Discussion Methanol is usually rapidly absorbed after ingestion and metabolized by alcohol dehydrogenase (ADH), then distributed to the body water to reach a volume distribution approximately equal to 0.77 L/kg. It is also eliminated from the body as unchanged parent compounds. Clinical manifestations of MP alone initiate within 0.5–4 h after ingestion and include gastrointestinal symptoms and CNS suppression. After a latent period of 6–24 h, depending on the absorbed dose, decompensated metabolic acidosis occurs with blurred vision and early or late blindness. Blurred vision with normal consciousness is a strong suspicious sign of an MP. The mortality and severity of intoxication are well associated with the severity of CNS depression, hyperglycemia, and metabolic acidosis, but not with serum methanol concentration. After initial resuscitation, the most important therapeutic action for patients with known or suspected MP is correction of acidosis, inhibition of ADH, and hemodialysis. Conclusion Since MP is associated with high morbidity and mortality, it should be considered seriously and instantly managed. Delay in treatment may cause complications, permanent damage, and even death.

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Section: Discussionmentioning

confidence: 99%

Methanol poisoning as a new world challenge: A review

Nekoukar

Zakariaei

Taghizadeh

et al. 2021

Annals of Medicine &Amp; Surgery

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“…29,32,33 Lesions associated with methanol toxicity have also been reported to show enhancement after gadolinium contrast administration. 31,34 One recent report of DWI performed in a patient with acute methanol intoxication showed bilateral striatal hyperintensities with reduced ADCs, consistent with restricted diffusion and cytotoxic edema. 34…”

Section: Methanolmentioning

confidence: 99%

“…29,30 Involvement of the corpus callosum has also been reported. 31 On MRI, the lesions generally appear hypointense on T1WI and hyperintense on T2WI (Fig. 3).…”

Section: Methanolmentioning

confidence: 99%

Neuroimaging of Toxic and Metabolic Disorders

Arora

Neema²,

Stankiewicz³

et al. 2008

Semin Neurol

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Imaging of the brain, magnetic resonance imaging (MRI) in particular, is a key adjunctive tool in the diagnosis and management of toxic-metabolic disorders such as alcoholism, mitochondrial encephalopathies, disorders of iron or copper metabolism, exposure to carbon monoxide, radiotherapy, immunosuppressive agents, toluene, and recreational drugs. In this article, we review the neuroimaging findings of common toxic and metabolic disorders focusing on the role of conventional MRI. We also consider advanced imaging methods, such as magnetic resonance spectroscopy, diffusion MRI, and positron emission tomography. We hope this article will prove useful to trainees and practitioners in the clinical and imaging fields of the neurosciences.

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Human Toxicity

Clary¹

2013

The Toxicology of Methanol

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Methanol poisoning with necrosis corpus callosum

Cited by 8 publications

References 1 publication

Methanol poisoning as a new world challenge: A review

Methanol poisoning as a new world challenge: A review

Neuroimaging of Toxic and Metabolic Disorders

Human Toxicity

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