Methemoglobinemia in rats injected with 3-nitropropanoic acid, sodium nitrite, and nitroethane

Matsumoto, Hiromu; Hylin, J. W.; Miyahara, Allen Y.

doi:10.1016/0041-008x(61)90040-0

Cited by 18 publications

(14 citation statements)

References 10 publications

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“…In agreement with previous studies on nitroalkanes, the NO2 (pg/ml-) : NPOH (pg/ml) ratio is low (approximately 1:20 at 2 h in Fig. lB), signifying the rapid metabolism of NO2 in vivo (Scott 1942;Matsumoto et al 1961). The proportion of metHb (7o) (Fig.…”

supporting

confidence: 92%

“…Range cattle and sheep are (Leguminosae) contains at least 263 species chronically or acutely poisoned by and varieties that synthesize aliphatic Astragalus species : that accumulate the nitrotoxins, presumably glycosides of 3-glycoside miserotoxin, or glucose esters of D-glucopyranoside (Stermitz and Yost 1978; 3-nitropropionic acid (NPA) (Williams and Williams and James 1978 (Williams and James 1975 (Scott 1942). Matsumoto et al (1961) For personal use only. <27 trials).…”

mentioning

confidence: 99%

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Toxicity and Metabolic Effects of Intravenously Administered 3-Nitropropanol in Cattle

Majak¹,

McDiarmid²,

Udenberg³

et al. 1981

Can. J. Anim. Sci.

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supporting

confidence: 92%

mentioning

confidence: 99%

Toxicity and Metabolic Effects of Intravenously Administered 3-Nitropropanol in Cattle

Majak¹,

McDiarmid²,

Udenberg³

et al. 1981

Can. J. Anim. Sci.

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“…At the end of period 1, ruminal inocula were obtained at 3 and 6 h after feeding (AF) to compare postprandial rates with prefeeding (PF) rates. For the treated group, average rates for NPOH were 166 (PF), Since methemoglobin (metHb) can be elevated by the release of nitrite from nitroalkanes (Matsumoto et al, 1961), % metHb was determined 1.5 and 3 h after nitroethane treatment. The average concentration of metHb for the nitroethane treatment was 1.20 -+ .26% and 1.36 +-.51% at 1.5 and 3 h, respectively., as compared with 1.22 -+ .67% for the control treatment.…”

Section: Expmentioning

confidence: 99%

Enhanced Degradation of 3-Nitropropanol by Ruminal Microorganisms

Majak

Cheng

Hall

1986

Journal of Animal Science

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Ruminal fluid was obtained over a 4-yr period from cattle on various diets and supplements to determine the effects of different inocula on the microbial degradation of 3-nitropropanol (NPOH), a toxic metabolite in certain Astragalus spp. (Leguminosae). Nitrite (NO2-) metabolism was also studied in vitro because rapid NO2- reduction is required for the overall detoxification of NPOH. Intra-ruminal supplements of sulfite were ineffective and produced toxic signs in treated animals. Ruminal fluid from cattle on fresh pasture diets enhanced the in vitro metabolism of NO2-, but rates of NPOH disappearance were not significantly affected. Rates of NPOH degradation increased when orchardgrass pasturage was supplemented with molasses. Enhancement of NPOH degradation was achieved with supplements of nitroethane given intra-ruminally at 6.5 or 10 mg/kg body weight. The effect of nitroethane on NO2- reduction was not always observed, but the NO2- rates of metabolism always exceeded those of NPOH. The rate of NPOH degradation also increased when nitroethane was added to a molasses supplement. However, the volatility of nitroethane under field conditions prompted a search for a more stable inducer and the sodium salt of nitroethane was subsequently evaluated. The salt of nitroethane, given intra-ruminally at 20 mg nitroethane/kg body weight, resulted in the highest rate of NPOH degradation; this was similar to that reported for 3-nitropropionic acid, a nitroalkane that is much less toxic to ruminants than NPOH.

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“…The chronic disease of cattle produced by miserotoxin is characterized by posterior weakness, incoordination, knuckling of the fetlocks (Williams & James, 1978), and nerve fiber degeneration in spinal cord and peripheral nerve (James et al, 1980). NPA or NPOH administration to animals is associated with methemoglobinemia, suggesting i n uiuo metabolism to nitrite (Matsumoto, Hylin & Miyahara, 1961). Animals intoxicated with doses of sodium nitrite that produce a larger degree of methemoglobinemia than clinically affected, NPA-intoxicated animals, fail to show clinical signs (Matsumoto, et al, 1961).…”

Section: Introductionmentioning

confidence: 99%

“…NPA or NPOH administration to animals is associated with methemoglobinemia, suggesting i n uiuo metabolism to nitrite (Matsumoto, Hylin & Miyahara, 1961). Animals intoxicated with doses of sodium nitrite that produce a larger degree of methemoglobinemia than clinically affected, NPA-intoxicated animals, fail to show clinical signs (Matsumoto, et al, 1961).…”

Section: Introductionmentioning

confidence: 99%

Basal Ganglia Degeneration, Myelin Alterations, and Enzyme Inhibition Induced in Mice by the Plant Toxin 3‐nitropropanoic Acid

Gould

Gustine

1982

Neuropathology Appl Neurobio

119

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The plant toxin, 3-nitropropanoic acid, produced topographically and morphologically distinctive lesions in mice after daily intraperitoneal injections. In the lateral caudate-putamen there were bilateral and symmetrical lesions consisting of marked swelling and pyknosis of individual cells and processes in otherwise unaffected tissue. The appearance of transitional forms and the usual post-synaptic location of the swollen processes indicated that affected cells were neurons. A few mice exhibited a more diffuse spongy change in the lateral caudate-putamen that caused major architectural changes. In the globus pallidus, entopeduncular nucleus, and anterior substantia nigra pars reticulata there was fine spongy change of the neuropil that spared cell bodies, and was primarily due to swelling of dendrites. A third lesion pattern in myelinated tracts of the midbrain, medulla, and spinal cord consisted of adaxonal, intramyelinic cleft formation. Succinate dehydrogenase activities assayed in frozen brain sections and in isolated mitochondria were markedly reduced in intoxicated mice.

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Methemoglobinemia in rats injected with 3-nitropropanoic acid, sodium nitrite, and nitroethane

Cited by 18 publications

References 10 publications

Toxicity and Metabolic Effects of Intravenously Administered 3-Nitropropanol in Cattle

Toxicity and Metabolic Effects of Intravenously Administered 3-Nitropropanol in Cattle

Enhanced Degradation of 3-Nitropropanol by Ruminal Microorganisms

Basal Ganglia Degeneration, Myelin Alterations, and Enzyme Inhibition Induced in Mice by the Plant Toxin 3‐nitropropanoic Acid

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