Methicillin-resistant and -sensitive Staphylococcus aureus nasal colonization of insulin-dependent children with juvenile onset diabetes mellitus

Prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus in children with diabetes mellitus: Trends between 2005 and 2013

“…Despite the relatively fewer number of studies on children with DM, reported MRSA colonization rates are significantly lower in comparison with studies on adult populations. 3,4 This could be attributed to the shorter follow-up periods in children after a diagnosis is confirmed and to a lower prevalence of complications, such as chronic renal failure and diabetic foot, which are known to increase the risk of MRSA colonization.…”

“…1 Prolonged length of hospital stay, recent history of hospitalization, regular nursing home contact (eg, nursing home residents), history of exposure to health careeassociated pathogens, diabetes mellitus (DM), and burns are established risk factors for nasal MRSA colonization. [1][2][3][4] Data on the epidemiology of MRSA in healthy Turkish individuals are limited, and available studies report on a low prevalence between 0.1% and 0.3%. 5,6 Nasal colonization rates in children and adolescents with type 1 DM have been evaluated in only 1 study, 3 in contrast with the few adult studies that may be encountered in the English literature.…”

“…[1][2][3][4] Data on the epidemiology of MRSA in healthy Turkish individuals are limited, and available studies report on a low prevalence between 0.1% and 0.3%. 5,6 Nasal colonization rates in children and adolescents with type 1 DM have been evaluated in only 1 study, 3 in contrast with the few adult studies that may be encountered in the English literature. 4,7 To our knowledge there is no published study in which trends in the prevalence of nasal colonization have been explored on outpatients with type 1 DM.…”

Staphylococcus aureus nasal carriage might be associated with vitamin D receptor polymorphisms in type 1 diabetes

“…The anterior nares are the primary ecological reservoir of S. aureus, and nasal carriage has been related to progress to staphylococcal disease. [13][14][15][16][17][18][19][20] The host's response seems to be crucial in S. aureus nasal colonization and carriage, but little is known in this field. 20 Vitamin D metabolites are known to affect macrophage activation, and neutrophils have been demonstrated to express functional VDR, 10,21 hence VDR gene polymorphisms may affect colonization and infection by microorganisms such as S. aureus that might behave as an intracellular pathogen.…”

Staphylococcus aureus infections in pediatric patients with diabetes mellitus

“…27 The studies differ widely in the percentage of adult and pediatric diabetes patients that are S. aureus carriers, with rates ranging from 11 to 76%. 28,29 Furthermore, S. aureus nasal colonization rates tended to be greater for patients with a higher (>9%) hemoglobin A1c. 28 In the present study, pediatric diabetes patients presenting with S. aureus infections between 2002 and 2010 were evaluated.…”