Methicillin-Resistant Staphylococcus schleiferi Subspecies coagulans Infection in a Patient With Hepatocellular Carcinoma

Abstract

To our knowledge and literature search, Staphylococcus schleiferi subspecies coagulans infection in human beings has rarely been described in the medical literature. Furthermore, we believe that this is a first detailed case report of methicillin-resistant Staphylococcus schleiferi subspecies coagulans infection in a patient with hepatocellular carcinoma. Because of the possible association of Staphylococcus schleiferi infection and immunosuppression, any isolates of this bacterium in human beings should be presumed to be pathogenic, unless proven otherwise.

First human case of catheter-related blood stream infection caused by Staphylococcus schleiferi subspecies coagulans: a case report and literature review

“…Non-aureus Staphylococci , especially coagulase-negative Staphylococci are often resistant to methicillin [ 20 ], however, two previous cases and the present case were susceptible to methicillin [ 5 , 11 – 13 ].…”

“…Only four cases of S. schleiferi subsp . coagulans infection have been reported previously including two cases of endocarditis [ 5 , 11 ], a case with left ventricular assist device infection [ 12 ], and a case with bacteremia (entry site undescribed) [ 13 ] (Table 1 ). None of the patients died of S. schleiferi subsp .…”

Antimicrobial Resistance, an Update from the Ward: Increased Incidence of New Potential Pathogens and Site of Infection-Specific Antibacterial Resistances

“…Despite the vast majority of isolates belonging to commensal and opportunistic pathogen species, some species usually not associated with infections were identified, potentially indicating the expansion of the range of pathogenic bacteria due to an increase in the exposure to such species, in the susceptibility of individuals or in the pathogenic potential of these bacteria. The first hypothesis is not likely as humans have been exposed for decades to the potential new pathogens: the listed Staphylococcus species are commonly isolated from pigeons, dogs, and cats [18][19][20] and Agrobacterium radiobacter is an environmental species. Contrarily, the latter two hypotheses are both plausible, as the very few reports on infections caused by these species in humans have always been observed in patients suffering from debilitating diseases [20].…”

“…The first hypothesis is not likely as humans have been exposed for decades to the potential new pathogens: the listed Staphylococcus species are commonly isolated from pigeons, dogs, and cats [18][19][20] and Agrobacterium radiobacter is an environmental species. Contrarily, the latter two hypotheses are both plausible, as the very few reports on infections caused by these species in humans have always been observed in patients suffering from debilitating diseases [20]. The higher frequency of hospital-acquired than community-acquired infections observed in this study could also be the result of several factors.…”

Staphylococcous epidermidis, Staphylococcous schleiferi Infections: Are CoNS Cons?

“…Infections with CoNS can be grueling to treat due to diverse vulnerabilities among strains and multidrug resistance. 1 , 2 …”