Methicillin-resistant Staphylococcus pseudintermedius: an underestimated risk at pet clinic

Abstract

The prevalence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) as a cause of infectious disease in companion animals remains unknown. The emergence of MRSP is a challenge in veterinary medicine as multidrug-resistant strains began to emerge, resulting in treatment failures. This study provides an overview of the characterization of S. pseudintermedius strains from clinical pet samples and the prevalence of MRSP strains. A total of 123 S. pseudintermedius strains were characterized by phenotypic testing and the MALDI-TOF technique and evaluated for susceptibility to methicillin and the presence of the mecA gene. Of these, 49 (39.8%) were identified as MRSP. The results confirm the importance of monitoring resistant pathogens and the need for further studies to determine the prevalence of MRSP in companion animals. The prevalence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) as a cause of infectious disease in companion animals remains unknown. This study provides an overview of the characterization of S. pseudintermedius strains from clinical pet samples and the prevalence of MRSP strains. A total of 123 S. pseudintermedius strains were characterized by phenotypic testing and the MALDI-TOF technique and evaluated for susceptibility to methicillin and the presence of the mecA gene. Of these, 49 (39.8%) were identified as MRSP. The results confirm the importance of monitoring resistant pathogens and the need for further studies to determine the prevalence of MRSP in companion animals.

Antimicrobial Activity of the Iron-Chelator, DIBI, against Multidrug-Resistant Canine Methicillin-Susceptible Staphylococcus pseudintermedius: A Preliminary Study of Four Clinical Strains

“…We have shown that four canine strains of S. pseudintermedius obtained from the University Veterinary Teaching Hospital in Naples, Italy, had multidrug resistance (MDR) profiles, being resistant to antimicrobial agents that are frequently prescribed for dogs with both MRSP and MSSP infections. Our findings are consistent with those of others, showing the broad, worldwide, increasing prevalence of antimicrobial-resistant S. pseudintermedius strains in dogs [17][18][19]. In addition, MSSP strains have shown increased resistance to most of the antimicrobials currently licensed for use in pets [3,4,[20][21][22][23][24].…”

Antimicrobial and Antibiofilm Effect of 4,4′-Dihydroxy-azobenzene against Clinically Resistant Staphylococci

“…The prevalence of antibiotic multiresistant bacteria is one of the more significant problems and highlights the urgent need for alternatives to antibiotics [ 2 , 3 ]. Methicillin-resistant S. pseudintermedius and S. aureus (MRSA) cause most of the cutaneous infections in pets and can be transmitted to humans, with the number of zoonotic infections caused by these pathogens raising [ 14 , 15 ]. In particular, methicillin-resistant S. aureus is one of the most prevalent human and animal pathogens [ 15 , 45 ].…”

“…In particular, methicillin-resistant S. aureus is one of the most prevalent human and animal pathogens [ 15 , 45 ]. Moreover, S. pseudintermedius causes the majority of skin infections in pets and can be also transmitted to humans as a zoonotic pathogen, with many of the isolates being methicillin resistant [ 11 , 12 , 13 , 14 , 46 , 47 ]. Moreover, the appearance of multiresistant strains and limitations on the use some antibiotics reserved for only human use due to precautionary principles sometimes makes the treatment of infections in animals challenging [ 48 , 49 ].…”

“…In addition to this problem in human health, the restrictions on veterinarians accessing to latest generation of antibiotics—whose use is normally hospital-restricted to limit the spread of resistance—presents a very complicated scenario at the time of treating these infections [ 9 , 10 ]. In fact, S. pseudintermedius , followed by S. aureus strains, is responsible for most of the skin infection cases observed in animals and is being envisioned as a significant and critical health problem due to its zoonotic potential [ 11 , 12 , 13 , 14 ]. In this sense, wild animals are considered as reservoirs and sentinels of methicillin-resistant S. aureus , a problem that must be envisioned from the One Health perspective [ 15 ].…”

Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry in veterinary medicine: Recent advances (2019–present)

“…Thus, MALDI-TOF can be a useful tool in screening cattle for the presence of the more hazardous clinically relevant version. Holmström et al [99] tackled the issue of prevalence of methicillin-resistant S. pseudintermedius in companion animals (dogs and cats). Isolates obtained from clinical samples were confirmed as isolates of S. pseudintermedius using MALDI-TOF.…”