Methionine and methionine sulfoxide induces neurochemical and morphological changes in cultured astrocytes: Involvement of Na+, K+-ATPase activity, oxidative status, and cholinergic and purinergic signaling

Soares, Mayara Sandrielly Pereira; Pedra, Nathália Stark; Bona, Natália Pontes; Souza, Anita Ávila de; Teixeira, Fernanda Cardoso; Azambuja, Juliana H.; Wyse, Ângela T. S.; Braganhol, Elizandra; Stefanello, Francieli Moro; Spanevello, Rosélia Maria

doi:10.1016/j.neuro.2019.12.013

NeuroToxicology

2020

DOI: 10.1016/j.neuro.2019.12.013

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Methionine and methionine sulfoxide induces neurochemical and morphological changes in cultured astrocytes: Involvement of Na+, K+-ATPase activity, oxidative status, and cholinergic and purinergic signaling

Mayara Sandrielly Pereira Soares

Nathália Stark Pedra

Natália Pontes Bona

et al.

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Cited by 6 publications

(1 citation statement)

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“…[5][6][7][8] Abnormal levels of L-Met can also lead to stunted growth and development, cardiovascular diseases, thrombosis, cancer cell alterations, liver damage, and cerebral edema. 6,9 These pathologies make the quantification of L-Met of great importance in biological systems. Even though several techniques namely colorimetry, 10 fluorometric detection, Liquid Chromatography (LC), 11 or Gas Chromatography-Mass Spectrometry (GCMS) in combination with UV, 12,13 atomic absorption, 14 flow injection 15 have been reported for the quantification of L-Met.…”

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confidence: 99%

High-Performance β-cyclodextrin-Ti₃C₂T_x MXene-Based Electrochemical Sensor for the Detection of Neurological Disorder Biomarker

Rajeev,

Varghese

2024

J. Electrochem. Soc.

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In this work, the β-cyclodextrin-MXene (β-CD-MXene) composite was employed as a modifier for carbon fiber paper (CFP) electrodes and quantification of L-methionine (L-Met). The β-CD-MXene composite was prepared by hydrothermal synthesis route by adding β-CD and Ti3C2Tx MXenes obtained via the Minimally intensive layer delamination technique. Cyclic voltammetry (CV) and Differential Pulse Voltammetry (DPV) were conducted to study the influence of scan rate and pH on the electrooxidation of L-Met studies using the β-CD-MXene/CFP electrode. The layered structure of the exfoliated Ti3C2Tx MXenes with charge transfer efficiency in combination with the host-guest interaction ability of β-CD enhances the electrooxidation of L-Met. The β-CD-MXene/CFP electrode showcased high sensitivity, reproducibility, and stability, and the anodic peak currents were in linearity with L-Met concentration within the range of 0.09–540 μM and LOD of 0.03 μM under various optimized conditions. In addition, the developed sensor showcases highly selective and non-interfering sensing of L-Met.

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confidence: 99%

High-Performance β-cyclodextrin-Ti₃C₂T_x MXene-Based Electrochemical Sensor for the Detection of Neurological Disorder Biomarker

Rajeev,

Varghese

2024

J. Electrochem. Soc.

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Chemical hypermethioninemia in young mice: oxidative damage and reduction of antioxidant enzyme activity in brain, kidney, and liver

et al. 2022

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High levels of methionine (Met) and its metabolites, such as methionine sulfoxide (MetO), found in hypermethioninemia, can be detrimental to the body; however, the underlying mechanisms are still uncertain. Using a recently standardized protocol, the aim of this study was to investigate the effects of chronic administration of Met and/or MetO on parameters of oxidative damage in the total brain, liver, and kidney of young mice. Swiss male mice were subcutaneously injected with Met and MetO at concentrations of 0.35-1.2 g/kg body weight and 0.09-0.3 g/kg body weight, respectively, from the 10th − 38th day post-birth, while the control group was treated with saline solution. Results showed that Met and/or MetO caused an increase in reactive oxygen species (ROS) and lipoperoxidation, along with a reduction of superoxide dismutase (SOD) and catalase (CAT) activities in the brain. In the liver, Met and/or MetO enhanced ROS and nitrite levels, and reduced SOD, CAT, and delta aminolevulinic dehydratase activities. The effects on the kidney were an increase in ROS production and SOD activity, and a reduction in thiol content and CAT activity. These data demonstrated the contribution of redox imbalance to the systemic changes found in patients with hypermethioninemia. In conclusion, our ndings may help future studies to better understand the pathophysiological mechanisms of hypermethioninemia as well as contribute to the search for new therapeutic agents for this pathology.

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Sensing of L-methionine in biological samples through fully 3D-printed electrodes

Kalinke

Neumsteir

Oliveira

et al. 2021

Analytica Chimica Acta

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Methionine and methionine sulfoxide induces neurochemical and morphological changes in cultured astrocytes: Involvement of Na+, K+-ATPase activity, oxidative status, and cholinergic and purinergic signaling

Cited by 6 publications

References 42 publications

High-Performance β-cyclodextrin-Ti₃C₂T_x MXene-Based Electrochemical Sensor for the Detection of Neurological Disorder Biomarker

High-Performance β-cyclodextrin-Ti₃C₂T_x MXene-Based Electrochemical Sensor for the Detection of Neurological Disorder Biomarker

Chemical hypermethioninemia in young mice: oxidative damage and reduction of antioxidant enzyme activity in brain, kidney, and liver

Sensing of L-methionine in biological samples through fully 3D-printed electrodes

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Methionine and methionine sulfoxide induces neurochemical and morphological changes in cultured astrocytes: Involvement of Na+, K+-ATPase activity, oxidative status, and cholinergic and purinergic signaling

Cited by 6 publications

References 42 publications

High-Performance β-cyclodextrin-Ti3C2Tx MXene-Based Electrochemical Sensor for the Detection of Neurological Disorder Biomarker

High-Performance β-cyclodextrin-Ti3C2Tx MXene-Based Electrochemical Sensor for the Detection of Neurological Disorder Biomarker

Chemical hypermethioninemia in young mice: oxidative damage and reduction of antioxidant enzyme activity in brain, kidney, and liver

Sensing of L-methionine in biological samples through fully 3D-printed electrodes

Contact Info

Product

Resources

About

High-Performance β-cyclodextrin-Ti₃C₂T_x MXene-Based Electrochemical Sensor for the Detection of Neurological Disorder Biomarker

High-Performance β-cyclodextrin-Ti₃C₂T_x MXene-Based Electrochemical Sensor for the Detection of Neurological Disorder Biomarker