Methionine as a safe and effective novel biorational mosquito larvicide

Weeks, Emma N.I.; Baniszewski, Julie; Gezan, Salvador A.; Allan, Sandra A.; Stevens, Bruce R.

doi:10.1002/ps.5118

Cited by 11 publications

(13 citation statements)

References 20 publications

(37 reference statements)

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“…albopictus and Cx. tarsalis [ 122 ], suggesting that similar processes could occur in mosquitoes. Another study in Drosophila showed that the production of lithocholic acid by the adult gut microbiota elongated host survival through upregulation of genes involved in glucose homeostasis [ 123 ], offering a potential target in the host to shorten lifespan.…”

Section: Influence Of Microbiota On Probability Of Vector Daily Survival (P)mentioning

confidence: 99%

The microbiome and mosquito vectorial capacity: rich potential for discovery and translation

et al. 2021

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Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. As in other animals, the gut-associated microbiota of mosquitoes affect host fitness and other phenotypes. It is now well established that microbes can alter pathogen transmission in mosquitoes, either positively or negatively, and avenues are being explored to exploit microbes for vector control. However, less attention has been paid to how microbiota affect phenotypes that impact vectorial capacity. Several mosquito and pathogen components, such as vector density, biting rate, survival, vector competence, and the pathogen extrinsic incubation period all influence pathogen transmission. Recent studies also indicate that mosquito gut-associated microbes can impact each of these components, and therefore ultimately modulate vectorial capacity. Promisingly, this expands the options available to exploit microbes for vector control by also targeting parameters that affect vectorial capacity. However, there are still many knowledge gaps regarding mosquito–microbe interactions that need to be addressed in order to exploit them efficiently. Here, we review current evidence of impacts of the microbiome on aspects of vectorial capacity, and we highlight likely opportunities for novel vector control strategies and areas where further studies are required.

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Section: Influence Of Microbiota On Probability Of Vector Daily Survival (P)mentioning

confidence: 99%

The microbiome and mosquito vectorial capacity: rich potential for discovery and translation

et al. 2021

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“…Mosquitoes are global disease vectors that transmit diseases such as malaria, Chikungunya and dengue fever. To limit the spread of these disease vector mosquitoes, researchers have identified larval mosquito control as a highly effective public health tool (Weeks et al, 2019). In particular, naturally occurring larvicides such as methionine and Bacillus sp.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, naturally occurring larvicides such as methionine and Bacillus sp. bacteria have recently increased in popularity as an environmentally safe alternative to synthetic insecticides such as DDT (Weeks et al, 2019;Regis et al, 2000). These larvicides must be ingested by larvae to be effective, and many factors affect larval feeding rate, including foraging strategy, chemosensory preference and competition with conspecifics or individuals from other species (Hartman, 2016;Ramoska and Hopkins, 1981;Merritt et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Distinct navigation behaviors in Aedes, Anopheles, and Culex mosquito larvae

Lutz

Riffell

2020

Journal of Experimental Biology

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Mosquitoes spread deadly diseases that impact millions of people every year. Understanding mosquito physiology and behavior is vital for public health and disease prevention. However, many important questions remain unanswered in the field of mosquito neuroethology, particularly in our understanding of the larval stage. In this study, we investigate the innate exploration behavior of six different species of disease vector mosquito larvae. We show that these species exhibit strikingly different movement paths, corresponding to a wide range of exploration behaviors. We also investigated the response of each species to an appetitive food cue, aversive cue or neutral control. In contrast to the large differences in exploration behavior, all species appeared to gather near preferred cues through random aggregation rather than directed navigation, and exhibited slower speeds once encountering food patches. Our results identify key behavioral differences among important disease vector species, and suggest that navigation and exploration among even closely related mosquito species may be much more distinct than previously thought.

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“…albopictus and Cx. tarsalis [109], suggesting that similar processes could occur in mosquitoes. Another study in Drosophila showed that the production of lithocholic acid by the gut microbiota elongated host survival through upregulation of genes involved in glucose homeostasis [110], offering a potential target in the host to shorten lifespan.…”

Section: Adult Nutrition and Fitnessmentioning

confidence: 84%

The Microbiome and Mosquito Vectorial Capacity: Rich Potential for Discovery and Translation

Cansado-Utrilla

Zhao

McCall

et al. 2020

Preprint

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Microbiome research has gained considerable interest due to the emerging evidence of its impact on human and animal health. Similar to higher organisms, the gut-associated microbiota of mosquitoes affect host fitness and other phenotypes. It is now well established that microbes can alter pathogen transmission in mosquitoes, either positively or negatively, and avenues are being explored to exploit microbes for vector control. However, less attention has been paid to how microbiota affect phenotypes that impact vectorial capacity. Several mosquito and pathogen components, such as vector density, biting rate, survival, vector competence and pathogen extrinsic incubation period all influence pathogen transmission. Interestingly, the mosquito gut-associated microbes can impact each of these components, and therefore ultimately modulate vectorial capacity. Promisingly, this expands the options available to exploit microbes for vector control by also targeting parameters that affect vectorial capacity. However, there are still many knowledge gaps in the biology of the mosquito – microbe symbiosis that need to be addressed in order to understand these interactions more thoroughly and exploit them efficiently. Here, we review current evidence of the impacts of the microbiome on aspects of vectorial capacity highlighting opportunities for novel vector control strategies and areas where further studies are required.

show abstract

Methionine as a safe and effective novel biorational mosquito larvicide

Cited by 11 publications

References 20 publications

The microbiome and mosquito vectorial capacity: rich potential for discovery and translation

The microbiome and mosquito vectorial capacity: rich potential for discovery and translation

Distinct navigation behaviors in Aedes, Anopheles, and Culex mosquito larvae

The Microbiome and Mosquito Vectorial Capacity: Rich Potential for Discovery and Translation

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