Methionine-induced hepatic coma in dogs

Merino, G E; Jetzer, T; Doizaki, William M.; Najarían, John S.

doi:10.1016/0002-9610(75)90454-7

Cited by 41 publications

(5 citation statements)

References 11 publications

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“…Meanwhile, methionine, as with lysine, is a precursor to the synthesis of carnitine, which is involved in the transport of fatty acids into the mitochondria for oxidation (Ala et al., 2019; Walton et al., 1982). A distinct oversupply of methionine + cystine can lead to toxic effects, like metabolic acidosis in weanling rates (Wamberg et al., 1987) or a hepatic coma in dogs (Merino et al., 1975). So it is one of key factors that optimum methionine intake can ensure the normal growth of animals.…”

Section: Discussionmentioning

confidence: 99%

Optimal dietary methionine requirement for juvenile sea cucumber Apostichopus japonicus selenka

Han

Wang

et al. 2020

Aquaculture Research

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This trial was conducted to determine the optimal dietary methionine requirement for juvenile sea cucumber Apostichopus japonicus selenka. Six isonitrogenous and isoenergetic experimental diets were formulated with graded methionine levels (0.18%, 0.37%, 0.57%, 0.78%, 0.96%, 1.10% dry matter). Each diet was assigned randomly to triplicate groups with 30 sea cucumbers juveniles with initial body weight 12.14 g in a recirculated aquaculture system for 56 days. Survival rate was not affected by dietary methionine. With the increase of dietary methionine levels, both weight gain and specific growth rate were significantly increased initially and then decreased afterwards. Both crude protein and crude lipid contents of body wall were evaluated firstly and dropped afterwards. meanwhile, contents of methionine, cystine, aspartic acid and total amino acids of body wall were all increased. Both total antioxidant capacity and total superoxide dismutase activities of intestine were increased, while malondialdehyde contents were decreased with the increase of dietary methionine. All of activities of protease and lipase were increased initially and then decreased afterwards; however, there was no significantly effect on amylase. In conclusion, analysis by a linear regression equation of WG or methionine contents in body wall indicated that the optimum requirement of methionine for juvenile sea cucumber (initial body weight 12.14 g) was 0.58%–0.72% diet (2.77%–3.42% diet protein).

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Section: Discussionmentioning

confidence: 99%

Optimal dietary methionine requirement for juvenile sea cucumber Apostichopus japonicus selenka

Han

Wang

et al. 2020

Aquaculture Research

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“…Hepatic vascular shunting, including AVF, does not induce tolerance to such drugs as methionine and certain tranquilizers (4,16 …”

Section: Methodsmentioning

confidence: 99%

Congenital Intrahepatic Arteriovenous Fistulae in a Young Beagle Dog

et al. 1997

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Congenital intrahepatic arteriovenous fistulae, a rare hepatic vascular anomaly, in an 8-mo-old female beagle dog was investigated. The animal showed anorexia, repeated vomiting, hemorrhagic diarrhea, and jaundice for approximately 2 wk. There was mild to severe increase of serum alkaline phosphatase, glutamic-oxalacetic transaminase, glutamic pyruvic transaminase, total cholesterol, total bilirubin, and γ-glutamyl transpeptidase. Macroscopically, the main abdominal organs showed hemorrhagic edema together with bloody ascites. Other characteristic findings were severe hepatic atrophy (right medial, quadrate, left medial, and lateral lobes) with multiple vascular cysts and compensatory hypertrophy of the other lobes. The cystic vessels seemed to extend from the proper hepatic arteries and their branches but were indistinguishable from the portal vein. Histopathologically, the atrophied hepatic lobes were characterized by wide, fibrous septa containing severe hyperplasia and anastomosis of the arteriolae and venulae and proliferation of bile ducts.

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“…[ 1 ] Until now, the prognostic significance of KRAS gene mutations has been unclear, as the results of previous studies are inconsistent. [ 2 – 15 ] Some studies showed that KRAS gene mutations were associated with worse overall survival (OS) in patients with CRC, [ 14 , 15 ] whereas other studies found no correlation. [ 2 , 5 ] However, most previous studies included mutations for both codon 12 and codon 13 genes in their analysis of prognosis, without distinguishing between the mutations.…”

Section: Introductionmentioning

confidence: 99%