Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53–p21 and p27 pathways

Lee, Eujin; Kwak, Geun-Hee; Kamble, Kranti; Kim, Hwa-Young

doi:10.1016/j.abb.2014.02.008

Cited by 28 publications

(21 citation statements)

References 30 publications

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“…Interestingly, the WNT effector pathway is essential for the initiation of embryonic mammary organogenesis and the maintenance of stem cells, and it may also regulate post-natal ductal and alveolar development25. Finally, it is worth to mention the methionine sulfoxide reductase B3 ( MSRB3 , 154.2 Mb) and the LEM domain containing 3 ( LEMD3 , 154.4 Mb) loci, that are involved in cell growth26 and skeletal development27, respectively.…”

Section: Resultsmentioning

confidence: 99%

Population structure of eleven Spanish ovine breeds and detection of selective sweeps with BayeScan and hapFLK

Manunza

Cardoso

Noce

et al. 2016

Sci Rep

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The goals of the current work were to analyse the population structure of 11 Spanish ovine breeds and to detect genomic regions that may have been targeted by selection. A total of 141 individuals were genotyped with the Infinium 50 K Ovine SNP BeadChip (Illumina). We combined this dataset with Spanish ovine data previously reported by the International Sheep Genomics Consortium (N = 229). Multidimensional scaling and Admixture analyses revealed that Canaria de Pelo and, to a lesser extent, Roja Mallorquina, Latxa and Churra are clearly differentiated populations, while the remaining seven breeds (Ojalada, Castellana, Gallega, Xisqueta, Ripollesa, Rasa Aragonesa and Segureña) share a similar genetic background. Performance of a genome scan with BayeScan and hapFLK allowed us identifying three genomic regions that are consistently detected with both methods i.e. Oar3 (150–154 Mb), Oar6 (4–49 Mb) and Oar13 (68–74 Mb). Neighbor-joining trees based on polymorphisms mapping to these three selective sweeps did not show a clustering of breeds according to their predominant productive specialization (except the local tree based on Oar13 SNPs). Such cryptic signatures of selection have been also found in the bovine genome, posing a considerable challenge to understand the biological consequences of artificial selection.

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Section: Resultsmentioning

confidence: 99%

Population structure of eleven Spanish ovine breeds and detection of selective sweeps with BayeScan and hapFLK

Manunza

Cardoso

Noce

et al. 2016

Sci Rep

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“…LHFP, a common ceRNA hub in all the four breast cancer subtypes is associated with mesenchymal differentiation in glioma [34]. Defective MSRB3 has been shown to inhibit cell proliferation through the activation of p53-p21 and p27 pathways [35]. Also, MSRB3 and LHFP co-regulate each other by sharing common hub miRNAs, miR-141-3p and miR-33a-5p (Figure 4C-4D; Pearson correlation coefficients are 0.74, 0.74, 0.65 and 0.63 in luminal A, luminal B, HER2-enriched and basal-like, respectively).…”

Section: Resultsmentioning

confidence: 99%

Competing endogenous RNA network analysis identifies critical genes among the different breast cancer subtypes

Chen

et al. 2016

Oncotarget

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Although competing endogenous RNAs (ceRNAs) have been implicated in many solid tumors, their roles in breast cancer subtypes are not well understood. We therefore generated a ceRNA network for each subtype based on the significance of both, positive co-expression and the shared miRNAs, in the corresponding subtype miRNA dys-regulatory network, which was constructed based on negative regulations between differentially expressed miRNAs and targets. All four subtype ceRNA networks exhibited scale-free architecture and showed that the common ceRNAs were at the core of the networks. Furthermore, the common ceRNA hubs had greater connectivity than the subtype-specific hubs. Functional analysis of the common subtype ceRNA hubs highlighted factors involved in proliferation, MAPK signaling pathways and tube morphogenesis. Subtype-specific ceRNA hubs highlighted unique subtype-specific pathways, like the estrogen response and inflammatory pathways in the luminal subtypes or the factors involved in the coagulation process that participates in the basal-like subtype. Ultimately, we identified 29 critical subtype-specific ceRNA hubs that characterized the different breast cancer subtypes. Our study thus provides new insight into the common and specific subtype ceRNA interactions that define the different categories of breast cancer and enhances our understanding of the pathology underlying the different breast cancer subtypes, which can have prognostic and therapeutic implications in the future.

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“…Our results suggested that diosgenin arrested cell cycle of primary human thyrocytes by downregulating cyclin D1. p21 and p27 prevent cell cycle progression by binding to cyclin-CDK complexes [20]. They are regarded as tumor suppressors as their upregulation inhibits proliferation of many cancer cells [21].…”

Section: Discussionmentioning

confidence: 99%

Diosgenin inhibits cell proliferation of primary human thyrocytes via downregulation of PI3K/Akt signaling pathway

Wen¹,

Yuxian²,

Xu³

et al. 2018

Trop. J. Pharm Res

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Purpose: To determine the potential influence of diosgenin on proliferation of human thyrocytes and its possible mechanism. Methods: Primary human thyrocytes were cultured and treated with diosgenin at various time intervals. Anti-proliferative activity was determined by MTT assay. Cell proliferation was evaluated by EdU assay while cell cycle was analyzed using fluorescence-activated cell sorting (FACS) method. Protein expression of p21 (CIP1), p27 (KIP1), cyclins, protein kinase B (Akt), phosphatidylinositol 3 kinase (PI3K) and p-Akt was determined by the western blot. Results: Diosgenin inhibited proliferation of primary human thyrocytes and caused G0/G1 arrest in a concentration-dependent manner. It also downregulated cyclin D1 and phosphorylation of PI3K and Akt, but upregulated p21 and p27. Conclusion: Inhibition of proliferation of primary human thyrocytes by diosgenin occurs via downregulation of PI3K/Akt signaling pathway. Therefore, diosgenin can be developed as a potential drug for the treatment of thyroid disease.

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Methionine sulfoxide reductase B3 deficiency inhibits cell growth through the activation of p53–p21 and p27 pathways

Cited by 28 publications

References 30 publications

Population structure of eleven Spanish ovine breeds and detection of selective sweeps with BayeScan and hapFLK

Population structure of eleven Spanish ovine breeds and detection of selective sweeps with BayeScan and hapFLK

Competing endogenous RNA network analysis identifies critical genes among the different breast cancer subtypes

Diosgenin inhibits cell proliferation of primary human thyrocytes via downregulation of PI3K/Akt signaling pathway

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