“…Reduced MsrA and MsrB correlate with senile hair graying (Wood et al , ), epidermal damage (Schallreuter et al , ), and vitiligo (Zhou et al , ). Msr have also been implicated with neurodegenerative diseases such as Alzheimer's and Parkinson's disease (Glaser et al , ), auditory function and hearing loss (Kwon et al , ; Kim et al , ), visual deterioration (Pascual et al , ), and obesity (Styskal et al , ), and insulin resistance (Kaneto et al , ). As we have highlighted, mutation of Met192 (M192L and M192V) is recognized to be associated with Parkinson's disease (Foroud et al , ), the same site as the MetO, and its reduction by MsrB2.…”