Method for evaluating thrombin concentration based on the data of monitoring the viscoelastic properties of native blood in the process of hemocoagulation

Abstract

The process of native blood coagulation was studied with the resonant-acoustic method using the technology of low-frequency piezothromboelastography. It is shown that the experimental curve of time dependence of the piezoelectric sensor signal amplitude reflects the change in the rheological properties of blood during coagulation. A formula is obtained that relates the change in the concentration of thrombin to the rate of change in the complex coefficient of blood viscosity. A method has been developed for assessing thrombin concentration during fibrinogenesis based on the technology of piezothromboelastography using a resonant-acoustic method to determine the viscoelastic properties of whole blood. The results of calculating the thrombin concentration by this method are compared with the results of the thrombin generation test.