Due to the problems that the rolling force of seamless steel tube during tandem rolling process is affected by many factors, the calculation is complex and the accuracy is not enough. In order to improve the rolling force calculation accuracy of the tandem rolling mill, analyze the metal flow, stress distribution rules and cross section deformation characteristics during the rolling process of seamless steel tube, calculation of the rolling force was divided into the reduced-diameter area and the reduction of wall area, and a new calculation method was proposed, which concerns the rolling force in reduced-diameter area related to the material yield stress, friction coefficient and the crushing stress of the tube, while the rolling force in the reduction of wall area is only related to the material yield stress and the friction coefficient. The results show that the calculated rolling force is in agreement with the measured values with errors less than ±10%. The model satisfies the actual conditions and is applicable to engineering application.