Method for systemic anaphylactic challenge in the rat using subplantar route

Levine, Seymour; Saltzman, Arthur

doi:10.1016/0022-1759(94)00108-1

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Suggestive evidence for the i.v. component comes from a study showing systemic anaphylaxis in rats minutes after subplantar booster immunization (Levine and Saltzman, 1994) and anecdotal reports of anaphylaxis after booster immunizations by the footpad route. The footpad is one of the most distal anatomic sites for delivery of Ag to the lymphatics, which thereby increases the probability of lymph node retention of Ag.…”

Section: Route Of Injection and Number Of Injection Sitesmentioning

confidence: 99%

Review of Polyclonal Antibody Production Procedures in Mammals and Poultry

Hanly¹,

Artwohl²,

Bennett³

1995

ILAR Journal

133

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Section: Route Of Injection and Number Of Injection Sitesmentioning

confidence: 99%

Review of Polyclonal Antibody Production Procedures in Mammals and Poultry

Hanly¹,

Artwohl²,

Bennett³

1995

ILAR Journal

133

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“…Three fourths of the rats also received pertussis vaccine (2 ×10 10 organisms) in the dorsum of the same foot. Thirteen days later, the rats were challenged with 10 mg of ovalbumin or azoalbumin, 100 mg casein, or 0.1 ml mouse serum intravenously in male rats and by subplantar route in female rats [for other details, see [4][5][6].…”

Section: Methodsmentioning

confidence: 99%

Distribution of Small Intestinal Lesions in Anaphylaxis of Rats

Levine

Saltzman

1998

Int Arch Allergy Immunol

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Hemorrhage and congestion were not uniformly distributed along the small intestine during systemic anaphylaxis in rats. Duodenum had little hemorrhage and congestion and the terminal ileum had even less. Maximum involvement occurred in jejunum of 13% of rats, in ileum of 47%, and in both jejunum and ileum of 40%. Sequential scoring along the entire length of small intestine revealed different patterns of distribution with more than one peak of intensity in some of the rats. Within a lesioned area, banding was common except where hemorrhage and congestion were so severe as to obliterate all patterns. Banding represented a gradient of injury with respect to the vascular supply. The pale stripes (less severe hemorrhage) contained the penetrating vessels derived from the terminal mesenteric arcades. The dark stripes (more severe hemorrhage) did not contain such vessels. In addition, the mesenteric side of the intestine was less affected than the antimesenteric side. This constituted a second gradient that might also be related to the distance from the vascular supply. In both instances, proximity to larger blood vessels had a protective effect. These two gradients and the variable sites and patterns of distribution have not been described previously in intestinal anaphylaxis. Gradients and the variability of the distribution of lesions in intestinal anaphylaxis should be considered in experiments on pathogenesis and altered function.

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Metallic Tin Is an Adjuvant for Anaphylaxis in Rats

Levine

Saltzman

2004

BTER

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Metallic tin powder is known to have an adjuvant-like property, by which it increases the levels of natural antibodies and induced hemagglutinins, and it enhances the induction of allergic encephalomyelitis in rats. In the present work, metallic tin is shown to be an adjuvant for a different immunologic process, anaphylactic sensitization. The new data support the notion that metallic tin causes polyclonal B-cell activation with proliferation of plasma cells.

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Method for systemic anaphylactic challenge in the rat using subplantar route

Cited by 4 publications

References 9 publications

Review of Polyclonal Antibody Production Procedures in Mammals and Poultry

Review of Polyclonal Antibody Production Procedures in Mammals and Poultry

Distribution of Small Intestinal Lesions in Anaphylaxis of Rats

Metallic Tin Is an Adjuvant for Anaphylaxis in Rats

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