2015
DOI: 10.1016/j.chroma.2015.05.002
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Method transfer from high-pressure liquid chromatography to ultra-high-pressure liquid chromatography. II. Temperature and pressure effects

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Cited by 28 publications
(24 citation statements)
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References 28 publications
(44 reference statements)
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“…Much smaller effect has been reported for the retention of uncharged solutes compared to charged solutes with the pressure increase in a similar range [13]. Present results showed a large increase in retention for tocopherols that are uncharged solutes with larger size.…”
Section: Effect Of Temperature On Selectivity Of Polymeric Ods Phasesupporting
confidence: 56%
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“…Much smaller effect has been reported for the retention of uncharged solutes compared to charged solutes with the pressure increase in a similar range [13]. Present results showed a large increase in retention for tocopherols that are uncharged solutes with larger size.…”
Section: Effect Of Temperature On Selectivity Of Polymeric Ods Phasesupporting
confidence: 56%
“…The effect of pressure on solute retention is strongly affected by the combination of solute structure and stationary phase structure. The effect of pressure was shown to be more pronounced for charged solutes [13,14]. For small, uncharged, hydrophobic solutes, the effects were relatively small.…”
Section: Introductionmentioning
confidence: 87%
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“…The computed properties 16) showed that the hydrogen bond donor count, rotatable bond count, and topological polar surface area of cyclosporine A were smaller, while the calculated log P value was larger, than those of daptomycin and Des-Arg9-[Leu8]-bradykinin (Table 2). These physicochemical characteristics, which contribute to the favorable pharmaceutical properties of cyclosporine A, result from the following key structural features-1: its cyclic backbone structure and incorporation of a D-amino acid, which protect against proteolytic degradation and increase structural rigidity, 2: seven N-methyl groups, which reduce the number of amide groups available to act as hydrogen bond donors, and 3: intramolecular hydrogen bonds, which reduce the availability of amide NH protons.…”
Section: )mentioning
confidence: 99%
“…20) Therefore, at higher temperature, the increase in these rates results in an increase in the mass transfer rate, which in turn causes a sharpening of the peak shape and increase of the plate number. 17) This temperature effect, in addition to the use of a nonporous column, must contribute to the highly efficient analysis of cyclosporine A. Furthermore, decreasing the particle size also contributes to the decreases in the A and C terms of Eq.…”
Section: )mentioning
confidence: 99%