Methodische Untersuchungen zur Erythrozytenfiltration durch Polycarbonatfilter

Red blood cell aging as a model to influence pharmacologically the red cell filterability

“…the basis of our model, i.e., using aging of fleshly collected blood as a system to evaluate pharmacologic effects on RCD. That FR of whole blood represents the mean RCD of an erythrocyte population is concluded from investigations with hyperosmolar blood [10,11]. Figure 4 shows the plot of the median values from Expt.…”

“…However, FR reflects most probably the mean RCD of the respective red cell population; yet since hematocrit and PV or SV influence FR it is necessary to standardize the method to achieve absolute comparability [10], i.e., adjusted hematocrit (-5%) and suspension of the red cells in albumin solution (20-80 g/l). This would minimize the influence of such factors as varying numbers of erythrocytes, different-sized red cell aggregates, and differing viscosity of suspension media.…”