2011
DOI: 10.1186/1471-2288-11-14
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Methodological criteria for the assessment of moderators in systematic reviews of randomised controlled trials: a consensus study

Abstract: BackgroundCurrent methodological guidelines provide advice about the assessment of sub-group analysis within RCTs, but do not specify explicit criteria for assessment. Our objective was to provide researchers with a set of criteria that will facilitate the grading of evidence for moderators, in systematic reviews.MethodWe developed a set of criteria from methodological manuscripts (n = 18) using snowballing technique, and electronic database searches. Criteria were reviewed by an international Delphi panel (n … Show more

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Cited by 111 publications
(114 citation statements)
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“…We make a clear distinction between confirmatory prespecified subgroup analyses and exploratory subgroup analyses, where the former is used for hypothesis testing and the latter is hypothesis generating (33,34). We used the Bonferroni correction to adjust for multiple testing for the prespecified subgroup analyses only.…”
Section: Discussionmentioning
confidence: 99%
“…We make a clear distinction between confirmatory prespecified subgroup analyses and exploratory subgroup analyses, where the former is used for hypothesis testing and the latter is hypothesis generating (33,34). We used the Bonferroni correction to adjust for multiple testing for the prespecified subgroup analyses only.…”
Section: Discussionmentioning
confidence: 99%
“…4,26,41,53 Statistical methods for creating the model should maximize the chance that the model will maintain its predictive performance when applied to future patients. 28,59 Consideration of all potentially important predictors during initial model development frequently requires analyzing a large number of clinical variables.…”
Section: T T Resultsmentioning
confidence: 99%
“…A treatment effect modifier is a factor that results in a greater treatment effect in one group compared with another and is best identified through randomized controlled trials. Identification of treatment effect moderators future science group www.futuremedicine.com provides information about which patients and under which conditions a particular treatment is most effective [15]. The mechanisms of action underpinning these moderating factors are similar and overlap supraspinal regions mediating MT pain relief.…”
Section: Moderating For Effectiveness Of Mtmentioning
confidence: 99%
“…As such treatment effect mediators are measured during treatment to determine if changes in the mediating variable in question impact a particular outcome. Once identified, mediating variables are capable of providing additional information related to the process and potential mechanisms by which an intervention may be effective (or ineffective) [15]. In addition, treatment aimed at influencing a mediating variable (assuming it can be modified through direct treatment) may be used to improve the e ffectiveness of other interventions (e.g., MT).…”
Section: Introductionmentioning
confidence: 99%