Methodological improvements to meta-analysis of low dose rate studies and derivation of dose and dose-rate effectiveness factors

Little, Mark P.; Pawel, David J.; Abalo, Kossi; Hauptmann, Michael

doi:10.1007/s00411-021-00921-x

Cited by 5 publications

(1 citation statement)

References 23 publications

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“…However, recent reanalysis of some large animal datasets did not yield very strong evidence for the ameliorating effects of low dose-rate or low dose exposure on cancer risk ( Tran and Little 2017 ), although evidence of such dose rate effects is stronger when the less relevant endpoint of life shortening is used ( Haley et al 2015 ). This evidence relating to possible effects of dose rate is fairly weak, since we are comparing risks in moderate and high dose rate studies with those at low dose rate among very different study populations, with different periods of follow-up; nevertheless, what we have done is in the spirit of similar exercises that have been conducted in the epidemiological literature that attempt to assess dose rate effects ( Hoel 2018 ; Jacob et al 2009 ; Kocher et al 2018 ; Little et al 2021d ; Shore et al 2017 ; Walsh et al 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses

Little

Wakeford

Bouffler³

et al. 2022

Environment International

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Section: Discussionmentioning

confidence: 99%

Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses

Little

Wakeford

Bouffler³

et al. 2022

Environment International

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On the choice of methodology for evaluating dose-rate effects on radiation-related cancer risks

Walsh

Shore

Azizova

et al. 2021

Radiat Environ Biophys

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Recently, several compilations of individual radiation epidemiology study results have aimed to obtain direct evidence on the magnitudes of dose-rate effects on radiation-related cancer risks. These compilations have relied on meta-analyses of ratios of risks from low dose-rate studies and matched risks from the solid cancer Excess Relative Risk models fitted to the acutely exposed Japanese A-bomb cohort. The purpose here is to demonstrate how choices of methodology for evaluating dose-rate effects on radiation-related cancer risks may influence the results reported for dose-rate effects. The current analysis is intended to address methodological issues and does not imply that the authors recommend a particular value for the dose and dose-rate effectiveness factor. A set of 22 results from one recent published study has been adopted here as a test set of data for applying the many different methods described here, that nearly all produced highly consistent results. Some recently voiced concerns, involving the recalling of the well-known theoretical point—the ratio of two normal random variables has a theoretically unbounded variance—that could potentially cause issues, are shown to be unfounded when aimed at the published work cited and examined in detail here. In the calculation of dose-rate effects for radiation protection purposes, it is recommended that meta-estimators should retain the full epidemiological and dosimetric matching information between the risks from the individual low dose-rate studies and the acutely exposed A-bomb cohort and that a regression approach can be considered as a useful alternative to current approaches.

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Response to “On the choice of methodology for evaluating dose-rate effects on radiation-related cancer risks” by Walsh et al.

Little

Pawel

Abalo

et al. 2021

Radiat Environ Biophys

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Methodological improvements to meta-analysis of low dose rate studies and derivation of dose and dose-rate effectiveness factors

Cited by 5 publications

References 23 publications

Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses

Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses

On the choice of methodology for evaluating dose-rate effects on radiation-related cancer risks

Response to “On the choice of methodology for evaluating dose-rate effects on radiation-related cancer risks” by Walsh et al.

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