Odor pollution is nowadays recognized as a serious environmental concern. Italy still lacks a national regulation about odors, but several regions issued specific guidelines and regulations regarding odor emissions management, which combine olfactometric measurements with dispersion modeling for assessing odor impacts and verifying compliance with acceptability criteria. However, in cases of variable or diffuse sources, this approach is sometimes hardly applicable, because odor emission rates can hardly be estimated. In such cases, electronic noses, or more generally, Instrumental Odor Monitoring Systems (IOMS), represent a suitable solution for direct odor measurement. Accordingly, IOMS are explicitly mentioned in the most recent regional regulations as advanced tools for odor impact assessment. In Italy, data from instrumental odor monitoring have started to have regulatory value; thus the need arises to have specific quality programs to ensure and verify the reliability of IOMS outcomes. This paper describes the monitoring by a commercial electronic nose (EOS507F) of odors from an area dedicated to tire storage, a diffuse source with variable emissions over time, for which dispersion modeling is not applicable. The paper proposes also a protocol for IOMS performance testing in the field, to provide experimental data to support technical groups working on standardization both on the national and European level.