Methodology and Background for the World Health Organization Global Guidelines on the Prevention of Surgical Site Infection

Sway, Angie; Solomkin, Joseph S.; Pittet, Didier; Kilpatrick, Claire

doi:10.1089/sur.2017.076

Cited by 16 publications

(12 citation statements)

References 12 publications

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“…SSIs were defined by the US Centers for Disease Control and Prevention definitions for surgical site-infection surveillance. 11 At the end of the intervention period, an infection-control nurse who was blinded to patient group recorded the clinical data of patients in both groups.…”

Section: Study Descriptionmentioning

confidence: 99%

“…9 During the last few decades, several papers have been published on optimal AP, and in this regard international guidelines for surgical prophylaxis have been updated and propagated. 11 Despite this, studies have shown that optimal practice is not achieved in many hospitals, especially in developing countries. 12,13 The knowledge and attitudes of surgeons about appropriate SAP are important factors in the implementation of guidelines.…”

Section: Introductionmentioning

confidence: 99%

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<p>Optimizing compliance with surgical antimicrobial prophylaxis guidelines in patients undergoing gastrointestinal surgery at a referral teaching hospital in southern Iran: clinical and economic impact</p>

Mahmoudi

Ghouchani

Mahi-Birjand

et al. 2019

IDR

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Background: Antibiotic prophylaxis is one of the major approaches to prevent surgical site infection. Despite the availability of international guidelines on it, the practice of antibiotic prophylaxis is still far from optimal. This study aimed to assess the impact of guideline implementation on the rational use of prophylactic antibiotics and its cost-saving effect in gastrointestinal surgery by clinical pharmacist intervention. Methods: A pre and post intervention study was carried out between October 2017 and June 2018 on patients who underwent gastrointestinal surgery in a major referral teaching hospital in Shiraz, southern Iran. The intervention phase consisted of revising the institutional guidelines for surgical antimicrobial prophylaxis, assigning a clinical pharmacist to the surgical department, and arranging several meetings with the surgical department regarding the appropriate utilization of antibiotics. Differences in antibiotic utilization in patients before and after the intervention phase were compared. Exposures were surgical antimicrobial prophylaxis timing and agents, and main outcomes were incidence of surgical site infection and length of hospital stay. Results: A total of 430 patients were included in the post intervention phase, while 445 patients were included in the baseline evaluation. Promoting appropriate antibiotic use in the post intervention group had the potential to decrease medication costs by reducing unnecessary prescriptions and duration of antibiotic usage (P<0.001). In the pre intervention group, the mean cost of antibiotic prescriptions was 11.5 times that of the post intervention group. Mean hospitalization in the pre intervention group was greater than the post intervention group (P<0.001). Furthermore, our data revealed that the rate of postsurgery infection in the post intervention group was 3.03%, while this rate was 6.76% in the preintervention group (P=0.01). Conclusion: This study provides evidence that adherence to surgical antimicrobial prophylaxis guidelines increased the rational use of prophylactic antibiotics, with substantial cost savings in patients who underwent surgery.

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Section: Study Descriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Optimizing compliance with surgical antimicrobial prophylaxis guidelines in patients undergoing gastrointestinal surgery at a referral teaching hospital in southern Iran: clinical and economic impact</p>

Mahmoudi

Ghouchani

Mahi-Birjand

et al. 2019

IDR

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“…In 2016, the WHO launched the first global guideline on the use of antibiotic prophylaxis to prevent SSI [ 55 ]. The guideline will have applicability in all countries and be especially welcomed in developing countries [ 56 , 57 ]. The selection and application of prophylactic antibiotics should be conducted according to medical characteristics including the type of surgical incision, the possibility of infection, the type of potential pathogens and the prophylactic effect of antibiotics [ 58 ].…”

Section: Antimicrobial Agentsmentioning

confidence: 99%

Application of antimicrobial drugs in perioperative surgical incision

Xiao

Wang

et al. 2018

Ann Clin Microbiol Antimicrob

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Infection in surgical incision often results in poor wound healing, and one of the main factors for wound infection is the use of antimicrobial agents. Rational use of antibiotics is one of the key factors to prevent incision infection in general surgery. The number of current clinical studies on antibiotic use before and during surgery is greater than that of systematic studies on antibiotic use after surgery. For the rational use of antibiotics and improvement of wound healing rate, researchers around the world have gradually focused on the use of antibiotics after surgery. Despite the familiarity on the concept of “rational use of antibiotics”, few clear and systematic studies were conducted to elucidate the effect of different antibiotics on wound healing. Therefore, this review focuses on the use of different types of antimicrobial agents in surgical wounds.

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“…Антибиотикопрофилактика. Профилактическое введение антибиотиков должно быть проведено до кожного разреза (оптимально: за 30 мин -1 ч до начала операции), а не интраоперационно после пережатия пуповины [21][22][23][24]. Это обусловлено тем, что оптимальная концентрация антибиотика в тканях и крови создается между 30-й и 60-й минутой после его внутривенного введения.…”

Section: методика проведения анестезии при операции кесарева сеченияunclassified

Anesthesia during cesarean section

Куликов¹,

Ovezov²,

Shifman³

2018

Anesteziologiya I Reanimatologiya

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В статье представлены клинические рекомендации (протоколы лечения) по проведению анестезии при операции кесарева сечения. Рассмотрены вопросы показаний и противопоказаний к различным методам анестезии, алгоритмы ведения пациентов в зависимости от избранных методов анестезии с оценкой их результативности. Ключевые слова: операция кесарева сечения, общая анестезия, нейроаксиальная анестезия, осложнения анестезии, местные анестезирующие средства. Для корреспонденции: Шифман Ефим Муневич, доктор мед. наук, проф. каф. анестезиологии и реаниматологии ФУВ ГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»,

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Methodology and Background for the World Health Organization Global Guidelines on the Prevention of Surgical Site Infection

Cited by 16 publications

References 12 publications

<p>Optimizing compliance with surgical antimicrobial prophylaxis guidelines in patients undergoing gastrointestinal surgery at a referral teaching hospital in southern Iran: clinical and economic impact</p>

<p>Optimizing compliance with surgical antimicrobial prophylaxis guidelines in patients undergoing gastrointestinal surgery at a referral teaching hospital in southern Iran: clinical and economic impact</p>

Application of antimicrobial drugs in perioperative surgical incision

Anesthesia during cesarean section

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